ID   A0A2K5XAE2_MANLE        Unreviewed;       821 AA.
AC   A0A2K5XAE2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000000306.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000000306.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5XAE2; -.
DR   Ensembl; ENSMLET00000000815.1; ENSMLEP00000000306.1; ENSMLEG00000000712.1.
DR   GeneTree; ENSGT00940000164213; -.
DR   OMA; APYFRED; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF227; PROTOCADHERIN GAMMA-A12; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 4.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        689..714
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          75..133
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          134..242
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          243..347
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          348..452
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          453..562
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          579..683
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   821 AA;  89440 MW;  F1E3F0A11BC81463 CRC64;
     MIPERPHRDC KDLVLLGILL GILWETRCTQ IRYSVPEELE KGSRVGDISK HLGLEPRELA
     ERGVRIVPRG RTQLFALNPR SGSLVTAGRI DREELCMGAI KCQLNLDILI EDKVKIYGVE
     VEVRDINDNA PYFRESELEI KISENAATDM RFPLPHAWDP DIGKNSLQSY ELSPNTHFSL
     IVQNGADGSK YPELVLERAL DREEKAAHHL VLTASDGGDP VRTGTARIRV MVLDANDNAP
     AFAQPEYRAS VPENLAVGTQ LLVVNATDPD EGVNAEVRYS FRYVDDKAAQ VFKLDCNSGT
     ISTIGELDHE ESEFYQMEVQ AMDNAGYSAR AKVLITVLDV NDNAPEVVLT SLASSVPENS
     PRGTLIALLN VNDQDSEVNG QVICFIQGNL PFKLEKSYGN YYSLVTDIVL DREQVPSYNI
     TVTATDRGTP PLSTEIHILL NVADTNDNPP VFLQASYSAY IPENNPRGAS LVSVTAHDPD
     CEENAQITYS LAEDTVQGAP LSSYVSISSD SGVLYALSSF DYEQLRDLQV KVMARDNGHP
     PLSSNVSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDKDSGQ
     NAWLSYHLLK ASEPGLFAVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL
     TVAVADSIPK VLADLGSLES PVNSETSDLT LHLVVAVAAV SCVFLAFVIV LLALRLRRWH
     KSRLLQASEG GLTGAPASHF VGVDGVQAFL QTYSHEVSLT LDSRKSHPIL PQPNYADTLV
     SQESGGKSES LLLSGDSVFS KDSRALIQVS LYQIFSLSFL F
//