ID A0A2K5XDN4_MANLE Unreviewed; 582 AA.
AC A0A2K5XDN4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=LDL receptor related protein 8 {ECO:0000313|Ensembl:ENSMLEP00000001423.1};
GN Name=LRP8 {ECO:0000313|Ensembl:ENSMLEP00000001423.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000001423.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000001423.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A2K5XDN4; -.
DR Ensembl; ENSMLET00000006191.1; ENSMLEP00000001423.1; ENSMLEG00000005506.1.
DR GeneTree; ENSGT00940000154819; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 4.
DR SMART; SM00135; LY; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 4.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 4.
DR PROSITE; PS51120; LDLRB; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 503..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 189..203
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT DOMAIN 228..243
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 305..348
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 349..393
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 5..17
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 12..30
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 24..39
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 44..56
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 51..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 106..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 128..140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 135..153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 147..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 582 AA; 65184 MW; 41194F5BF07475D5 CRC64;
PAKECEKDQF QCRNERCIPS VWRCDEDDDC LDHSDEDDCP KKTCADSDFT CDNGHCIHER
WKCDGEEECP DGSDESEATC TKQVCPAEKL SCGPTSHKCV PASWRCDGEK DCEGGADEAG
CVTSLGTCHE NEFQCGDGTC VLAIKRCNQE QDCPDGSDEA GCLQGLNECL HNNGGCSHIC
TDLKIGFECT CPAGFQLLDQ KTCGDIDECK DPDACSQICV NYKGYFKCEC YPGYEMDLLT
KNCKAAAGKS PSLIFTNRHE VRRIDLVKRN YSRLIPMLKN VVALDVEVAT NRIYWCDLSY
RKIYRFMYWS DWGNQAKIEK SGLNGVDRQT LVSDNIEWPN GITLDLLSQR LYWVDSKLHQ
LSSIDFSGGN RKMLISSTDF LSHPFGIAVF EDKVFWTDLE NEAIFSANRL NGLEISILAE
NLNNPHDIVI FHELKQPRAA DACKLSVQPN GGCEYLCLPA PQISSHSPKY TCACPDTMWL
GPDMKRCYRD GNEDSKMGST VTAAVIGIIV PIVVIALLCM SGYLIWRNWK RKNTKSMNFD
NPVYRKTTEE EDEDELHIGR TAQIGHVYPA RVALSLEDDG LP
//
