ID   A0A2K5XDP4_MANLE        Unreviewed;       912 AA.
AC   A0A2K5XDP4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 5 {ECO:0000313|Ensembl:ENSMLEP00000001433.1};
GN   Name=ITIH5 {ECO:0000313|Ensembl:ENSMLEP00000001433.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000001433.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000001433.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   AlphaFoldDB; A0A2K5XDP4; -.
DR   Ensembl; ENSMLET00000006245.1; ENSMLEP00000001433.1; ENSMLEG00000005582.1.
DR   GeneTree; ENSGT00940000158317; -.
DR   OMA; AKKFIYT; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF62; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          5..131
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          265..448
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          178..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          518..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        528..542
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  101220 MW;  C758EE3461A8F48A CRC64;
     DGPRVPRQVR LLQRLKTKPL MTEFSVKSTI ISRYAFTTVS CRMLNRASED QDIEFQMQIP
     AAAFITNFTM LIGDKVYQGE ITERAKKSGD RVKEKRNKTT EENGEKGTEI FRASAVIPSK
     DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ LSGRLSVDVN ILESAGIASL EVLPLHNSRQ
     RGSGRGEDDS GPPPSTVINQ NETFANIIFK PSVVQQAKIA QNGVLGDFII RYDVNREQSI
     GDIQVLNGYF VHYFAPKDLP PLPKNVVFVL DSSASMVGTK LRQTKDALFT ILHDLRPQDR
     FSIIGFSNRI KVWKDHLISV TPDSIRDGKV YIHHMSPTGG TDINGALQRA IRLLNKYVAH
     NDIGDRSVSL IIFLTDGKPT VGETHTLKIL NNTREAARGQ VCIFTIGIGN DVDFRLLEKL
     SLENCGLTRR VHEEEDAGSQ LIGFYDEIRT PLLSDIRIDY PPSSVVQATK TLFPNYFNGS
     EIIIAGKLVD RKLDHLHVEV TASNSKKFVI LKTDVPVGPQ KAGKDVTGSS RPEGDGEGDP
     NHIERLWSYL TTKQLLSSWL QSDDEPEKER LRQRAQDLAL SYRFLTPFTS MKLRGPVPRK
     DGLEEAHGMS AAMGPEPVVQ SVRGAGTQPG PLLEKPYQPR IKISKTSVDG DPHFVVDFPL
     SKLTVCFNID GQPGDILRLV SDHMDSGVTV NGELIGAPAP PNGHKKQRTY FRTITILVNK
     PERSYLEITP SRVILDGGDR LVLPCNQSVV VGSRGLEVSV SANANVTVTI QGSIAFVILI
     HLYKKPAPFQ RHHLGFYIAN SEGLSSNCHG LLGQFLNQDA RLTEDPAGPS QSPTHLLLLQ
     AGEGPEAVLK VKGHQVPVVW KQRKIYNGEE QIDCWFARNN AAKLIDGEYK DYLASHPFDT
     GMTLGRGTSR EL
//