ID A0A2K5XF46_MANLE Unreviewed; 1387 AA.
AC A0A2K5XF46;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRG {ECO:0000313|Ensembl:ENSMLEP00000001930.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000001930.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000001930.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 5 subfamily. {ECO:0000256|ARBA:ARBA00006246}.
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DR Ensembl; ENSMLET00000008446.1; ENSMLEP00000001930.1; ENSMLEG00000007529.1.
DR GeneTree; ENSGT00940000155048; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd03122; alpha_CARP_receptor_like; 1.
DR CDD; cd00063; FN3; 1.
DR CDD; cd17670; R-PTP-G-2; 1.
DR CDD; cd17667; R-PTPc-G-1; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR041887; Alpha_CARP_receptor-type.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 708..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..292
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT DOMAIN 320..419
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 790..1061
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 978..1052
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1092..1352
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1269..1343
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 432..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..681
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1387 AA; 155134 MW; D2E3B9BF6795D3A9 CRC64;
LTEGYVGALH ENRHGSAVQI RRRKASGDPY WAYSGAYGPE HWVTSSVSCG GHHQSPVDIL
DQHARVGEEY QELQLDGFDN ESSNKTWMKN TGKTVAILLK DDYFVSGAGL PGRFKAEKVE
FHWGHSNGSA GSEHSIDGRR FPVEMQIFFY NPDDFDSFQT AISENRIIGA MAIFFQVSPR
DNSALDPIIH GLKGVVHHEK ETFLDPFVLR DLLPASLGSY YRYTGSLTTP PCSEIVEWIV
FRRPVPISYH QLEAFYSIFT TEQQDHVKSV EYLRNNFRPQ QRLHDRVVSK SAVRDAWNHD
VTDFLENPLG TEASKVCSSP PIHMKVQPLN QTALQVSWSQ PETIYHPPIM NYMISYSWTK
NEDEKEKTFT KDSDKDLKAT ISHVSPDSLY LFRVQAVCRN DMRSDFSQTM LFQANTTRIF
QGTRIVKTGV PTASPASSAD MAPISSGSST WTSSGIPFSF VSMATGMGPS SSGSQATVAS
VVTSTLLAGL GFGGGGISSF PSTVWPTRLP TAASASKQAA RPVLATTEAL ASPGPDGDSS
PTKDSEGTEE GEKDEKSESE DGEREHEEDG EKDSEKKEKS GVTHAAEERN QTEPSPTPSS
PNRTAEGGHH TIPGHEQDHT AIPTDQTGGR RDAGPGPDPD AVTSTQVPPT ATEEQYAGSD
PKRPEMPSKK PVSRGDRFSE DSRFITVNPA EKNTSGMISR PAPGRMEWII PLIVVSALTF
VCLILLIAVL VYWRKCFQTA HFYVEDSNSP RVVPNESIPI IPIPDDMEAI PVKQFVKHIG
ELYSNNQHGF SEDFEEVQRC TADMNITAEH SNHPENKHKN RYINILAYDH SRVKLRPLPG
KDSKHSDYIN ANYVDGYNKA KAYIATQGPL KSTFEDFWRM IWEQNTGIIV MITNLVEKGR
RKCDQYWPTE NSEEYGNIIV TLKSTKVHAC YTVRRFSVRN TKVKKGQKGN PKGRQNERIV
IQYHYTQWPD MGVPEYALPV LTFVRRSSAA RMPEMGPVLV HCSAGVGRTG TYIVIDSMLQ
QIKDKSTVNV LGFLKHIRTQ RNYLVQTEEQ YIFIHDALLE AILGKETEVS SNQLHSYVNS
ILIPGVGGKT RLEKQFKLVT QCNAKYVECF SAQKECNKEK NRNSSVVPSE RARVGLAPLP
GMKGTDYINA SYIMGYYRSN EFIITQHPLP HTTKDFWRMI WDHNAQIIVM LPDNQSLAED
EFVYWPSREE SMNCEAFTVT LISKDRLCLS NEEQIIIHDF ILEATQDDYV LEVRHFQCPK
WPNPDAPISS TFELINVIKE EALTRDGPTI VHDEYGAVSA GMLCALTTLS QQLENENAVD
VFQVAKMINL MRPGVFTDIE QYQFVYKAML SLVSTKENGN GPMTVDKNGA VLIADESDPA
ESMESLV
//
