ID   A0A2K5XFQ2_MANLE        Unreviewed;      1023 AA.
AC   A0A2K5XFQ2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO9 {ECO:0000313|Ensembl:ENSMLEP00000002140.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000002140.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000002140.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   STRING; 9568.ENSMLEP00000002140; -.
DR   Ensembl; ENSMLET00000009457.1; ENSMLEP00000002140.1; ENSMLEG00000008526.1.
DR   GeneTree; ENSGT00940000158300; -.
DR   OMA; PTHHPED; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF37; ANOCTAMIN-9; 1.
DR   Pfam; PF04547; Anoctamin; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        525..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        590..613
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        633..652
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        679..702
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          520..806
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   DOMAIN          832..976
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          175..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..230
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1023 AA;  115802 MW;  706D67244CCFABCB CRC64;
     MRDSLRILVE PEGDSFPLME IGTCEAEASE QWEYVLVAHH RTQGDPRQEQ FLEELRRKGF
     RTKTIQDQKR VFFGIRADNS IFDLYRTLLL EPEGPAPHAE LAAPTPVPVT TRIRIVNFVV
     MKTKTSAGET FEDLEKDGVF EAKFPLHKPG EGLGVGPWDG GWRHMFREQP VDEIRDHRNP
     TDAPRYPRDC HPRGCLHTTT AALTPVDAPT HHPEDAPTLP TPPQMPPCPQ TCSPFRLTDA
     TKGETRLPHP VPPTSTXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX FDNDGTVVFA IFMALWATVF
     LEIWKRQRAR VVLHWDLYTW DEDQEEMALQ LINCPDYKLR PHQHSYLRST VILILSLIMI
     CLMIGMAHIL VVYRVLASAL FSSSALPFLE DQVTTAVVVT GALVHYVTIS IMTKINKYVA
     LKLCDFEMPR THSERESRFT IRFFTLQFFT HFSSLIYIAF ILETACPGNN GTCSLCWKST
     QCLPGSCHAS GCMMDLFVQM AIIMGLKQTL SNCAEYLVPW VSHKFRSLRA SKAGHLPRDP
     ELRDWRRNYL LNSVNIFSLF DEFMEMSAWA LPLVHCSGGR TSRGRRVRPL VHCSGAGTWL
     QVLETIGVLA VIANGLVIAF TSEFIPRMVY KYRYSPCLKE ANSTVDCLKG YVNHSLSVFH
     TKDFQDPDRI EGSENVTLCR YRDYRNPPDY NFSEQFWFLL AIRLAFVILF EHVALCIKLI
     AAWFVPDVPQ SVKNKVLEVK YQRLREKMWH GRQRLGGVGA GSQPLMPADP TPTSIFSARS
     TDV
//