ID A0A2K5XHF7_MANLE Unreviewed; 469 AA.
AC A0A2K5XHF7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Mitogen-activated protein kinase 8 interacting protein 1 {ECO:0000313|Ensembl:ENSMLEP00000002731.1};
GN Name=MAPK8IP1 {ECO:0000313|Ensembl:ENSMLEP00000002731.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000002731.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000002731.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
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DR AlphaFoldDB; A0A2K5XHF7; -.
DR STRING; 9568.ENSMLEP00000002731; -.
DR Ensembl; ENSMLET00000012439.1; ENSMLEP00000002731.1; ENSMLEG00000011311.1.
DR GeneTree; ENSGT00940000157089; -.
DR OMA; GHHRERI; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0044302; C:dentate gyrus mossy fiber; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:2000564; P:regulation of CD8-positive, alpha-beta T cell proliferation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:Ensembl.
DR CDD; cd01212; PTB_JIP; 1.
DR CDD; cd11943; SH3_JIP1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR047178; JIP1_scaffold.
DR InterPro; IPR035638; JIP1_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47437:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR47437; JNK-INTERACTING PROTEIN 1-LIKE PROTEIN; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 244..305
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 322..444
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 52127 MW; 07B57C58869D98B4 CRC64;
MAPPGGPPAA PPGGRGHSHR DRIHYQADVR LEATEEIYLT PVQRPPDPAE PTSAFLPPTE
SRMSVSSDPD PAAYPSTAGR PHPSISEEEE GFDCLSSPER AEPPGGGWRG SLGEPPPPPR
ASLSSDTSAL SYDSVKYTLV VDEHAQLELV SLRPCFGDYS DESDSATVYD NCASVSSPYE
SAIGEEYEEA PRPQPPACLS EDSTPDEPDV HFSKKFLNVF MSGRSRSSSA ESFGLFSCII
NGEEQEQTHR AIFRFVPRHE DELELEVDDP LLVELQAEDY WYEAYNMRTG ARGVFPAYYA
IEVTKEPEHM AALAKNSDWV DQFRVKFLGS VQVPYHKGND VLCAAMQKIA TTRRLTVHFN
PPSSCVLEIS VRGVKIGVKA DDSQEAKGNK CSHFFQLKNI SFCGYHPKNN KYFGFITKHP
ADHRFACHVF VSEDSTKALA ESVGYVRAFQ QFYKQFVEYT CPTEDIYLE
//
