ID A0A2K5XLF0_MANLE Unreviewed; 883 AA.
AC A0A2K5XLF0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Transportin 2 {ECO:0000313|Ensembl:ENSMLEP00000004134.1};
GN Name=TNPO2 {ECO:0000313|Ensembl:ENSMLEP00000004134.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000004134.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000004134.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_011850338.1; XM_011994948.1.
DR AlphaFoldDB; A0A2K5XLF0; -.
DR Ensembl; ENSMLET00000020281.1; ENSMLEP00000004134.1; ENSMLEG00000018391.1.
DR GeneID; 105550086; -.
DR KEGG; mleu:105550086; -.
DR CTD; 30000; -.
DR GeneTree; ENSGT00940000156708; -.
DR OMA; AQEGAMS; -.
DR OrthoDB; 276400at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF17; TRANSPORTIN-2; 1.
DR Pfam; PF02985; HEAT; 2.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 17..85
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00913"
FT REGION 311..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 99942 MW; 6F5C169B5FFC3B21 CRC64;
MTCYWGELTS SCHFKRTWQK LKQLNQFPDF NNYLIFVLTR LKSEDEPTRS LSGLILKNNV
KAHYQSFPPP VADFIKQECL NNIGDASSLI RATIGILITT IASKGELQMW PELLPQLCNL
LNSEDYNTCE GAFGALQKIC EDSSELLDSD ALNRPLNIMI PKFLQFFKHC SPKIRSHAIA
CVNQFIMDRA QALMDNIDTF IEHLFALAVD DDPEVRKNVC RALVMLLEVR IDRLIPHMHS
IIQYMLQRTQ DHDENVALEA CEFWLTLAEQ PICKEVLASH LVQLIPILVN GMKYSEIDII
LLKGDVEEDE AVPDSEQDIK PRFHKSRTVT LPHEAERPDG SEDAEDDDDD DALSDWNLRK
CSAAALDVLA NVFREELLPH LLPLLKGLLF HPEWVVKESG ILVLGAIAEG CMQGMVPYLP
ELIPHLIQCL SDKKALVRSI ACWTLSRYAH WVVSQPPDMH LKPLMTELLK RILDGNKRVQ
EAACSAFATL EEEACTELVP YLSYILDTLV FAFGKYQHKN LLILYDAIGT LADSVGHHLN
QPEYIQKLMP PLIQKWNELK DEDKDLFPLL ECLSSVATAL QSGFLPYCEP VYQRCVTLVQ
KTLAQAMMYT QHPEQYEAPD KDFMIVALDL LSGLAEGLGG HVEQLVARSN IMTLLFQCMQ
DSMPEVRQSS FALLGDLTKA CFIHVKPCIA EFMPILGTNL NPEFISVCNN ATWAIGEICM
QMGAEMQPYV QMVLNNLVEI INRPNTPKTL LENTGRLTSP SAIPAITIGR LGYVCPQEVA
PMLQQFIRPW CTSLRNIRDN EEKDSAFRGI CMMIGVNPGG VVQDFIFFCD AVASWVSPKD
DLRDMFYKIL HGFKDQVGED NWQQFSEQFP PLLKERLAAF YGV
//
