ID A0A2K5XLR8_MANLE Unreviewed; 352 AA.
AC A0A2K5XLR8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Salvador family WW domain containing protein 1 {ECO:0000313|Ensembl:ENSMLEP00000004232.1};
GN Name=SAV1 {ECO:0000313|Ensembl:ENSMLEP00000004232.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000004232.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000004232.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5XLR8; -.
DR STRING; 9568.ENSMLEP00000004232; -.
DR Ensembl; ENSMLET00000020857.1; ENSMLEP00000004232.1; ENSMLEG00000019122.1.
DR GeneTree; ENSGT00940000156106; -.
DR OMA; AARYYYP; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR GO; GO:0035329; P:hippo signaling; IEA:Ensembl.
DR GO; GO:0060575; P:intestinal epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0097283; P:keratinocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0060487; P:lung epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:1902174; P:positive regulation of keratinocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR CDD; cd21433; SARAH_Sav; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR030030; Sav.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR47522:SF2; PROTEIN SALVADOR HOMOLOG 1; 1.
DR PANTHER; PTHR47522; SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50951; SARAH; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 168..201
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 203..236
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 290..337
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
SQ SEQUENCE 352 AA; 41035 MW; F049569124F7BF8F CRC64;
LMPSFIRHGP TIPRRTDICL PDSSPNAFST SGDGVVSRNQ SFLRTPIQRT PHEIMRRESN
RLSAPSYLAR SLADVPREYG SSQSFVTEVS FAVENGDSGS RYYYSDNFFD GQRKRPLGDR
AHEEYRYYEY NHDLFQRMPQ NQGRHASGIG RVAATSLGNL TNHGSEDLPL PPGWSVDWTM
RGRKYYIDHN TNTTHWSHPL EREGLPPGWE RVESSEFGTY YVDHTNKKAQ YRHPCAPSVP
RYDQPPPVTY QPQQTERNQS LLVPANPYHT AEIPDWLQVY ARAPVKYDHI LKWELFQLAD
LDTYQGMLKL LFMKELEQIV KMYEAYRQAL LTELENRKQR QQWYAQQHGK NF
//
