ID A0A2K5XPN9_MANLE Unreviewed; 3846 AA.
AC A0A2K5XPN9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Transformation/transcription domain associated protein {ECO:0000313|Ensembl:ENSMLEP00000005253.1};
GN Name=TRRAP {ECO:0000313|Ensembl:ENSMLEP00000005253.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000005253.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000005253.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR STRING; 9568.ENSMLEP00000005253; -.
DR Ensembl; ENSMLET00000025674.1; ENSMLEP00000005253.1; ENSMLEG00000020926.1.
DR GeneTree; ENSGT00390000017961; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0048584; P:positive regulation of response to stimulus; IEA:UniProt.
DR GO; GO:0080135; P:regulation of cellular response to stress; IEA:UniProt.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 2679..3262
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3487..3810
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3814..3846
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2009..2028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2531..2563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2014..2028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3846 AA; 436081 MW; 22B9F0A3EA2B17B2 CRC64;
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE NVTSSPQYST
FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI PTNEHLRPHT KNVLSVMFRF
LETENEENVL ICLRIIIELH KQFRPPITQE IHHFLDFVKQ IYKELPKVVN RYFENPQVIP
ENTVPPPEMV GMITTIAVKV NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK
LNIHNVVAEF VPLIMNTIAI QVSAQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQV
RSLTFMSDRV SLCCPGWSAV APSQLTVASA SLVQTILFIP CMDKLFDESI LIGSGYTARE
TLRPLAYSTL ADLVHHVRQH LPLSDLSLAV QLFAKNIDDE SLPSSIQTMS CKLLLNLVDC
IRSKSEQESG NGRDVLMRML EVFVLKFHTI ARYQLSAIFK KCKPQSELGA VEAALPGVPT
APAAPGPPLS LXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXT DCRSLVKTLV
CGVKTITWGI TSCKAPGEAQ FIPNKQLQPK ETQIYIKLVK YAMQALDIYQ VQIAGNGQTY
IRVANCQTVR MKEEKEVLEH FAGVFTMMNP LTFKEIFQTT VPYMVERISK NYALQIVANS
FLANPTTSAL FATILVEYLL DRLPEMGSNV ELSNLYLKLF KLVFGSVSLF AAENEQMLKP
HLHKIVNSSM ELAQTAKEPY NYFLLLRALF RSIGGGSHDL LYQEFLPLLP NLLQGLNMLQ
SGLHKQHMKD LFVELCLTVP VRLSSLLPYL PMLMDPLVSA LNGSQTLVSQ GLRTLELCVD
NLQPDFLYDH IQPVRAELMQ ALWRTLRNPA DSISHVAYRV LGKFGGSNRK MLKESQKLHY
VVTEVQGPSI TVEFSDCKAS LQLPMEKAIE TALDCLKSAN TEPYYRRQAW EVIKCFLVAM
MSLEDNKHAL YQLLAHPNFT EKTIPNVIIS HRYKAQDTPA RKTFEQALTG AFMSAVIKDL
RPSALPFVAS LIRHYTMVAV AQQCGPFLLP CYQVGSQPST AMFHSEENGS KGMDPLVLID
AIAICMAYEE KELCKIGEVA LAVIFDVASI ILGSKERACQ LPLFSYIVER LCACCYEQAW
YAKLGGVVSI KFLMERLPLT WVLQNQQTFL KALLFVMMDL TGEVSNGAVA MAKTTLEQLL
MRCATPLKDE ERAEEIVAAQ EKSFHHVTHD LVREVTSPNS TVRKQAMHSL QVLAQVTGKS
VTVIMEPHKE VLQDMVPPKK HLLRHQPANA QIGLMEGNTF CTTLQPRLFT MDLNVVEHKV
FYTELLNLCE AEDSALTKLP CYKSLPSLVP LRIAALNALA ACNYLPQSRE KIIAALFKAL
NSTNSELQEA GEACMRKFLE GATIEVDQIH THMRPLLMML GDYRSLTLNV VNRLTSVTRL
FPNSFNDKFC DQMMQHLRKW MEVVVITHKG GQRSDGNESI SECGRCPLSP FCQFEEMKIC
SAIINLFHLI PAAPQTLVKP LLEVVMKTER AMLIEAGSPF REPLIKFLTR HPSQTVELFM
MEATLNDPQW SRMFMSFLKH KDARPLRDVL AANPNRFITL LLPGGAQTAV RPGSPSTSTM
RLDLQFQAIK IISIIVKNDD SWLASQHSLV SQLRRVWVSE TFQERHRKEN MAATNWKEPK
LLAYCLLNYC KRNYGDIELL FQLLRAFTGR FLCNMTFLKE YMEEEIPKNY SITQKRALFF
RFVDFSDPNF GDELKAKVLQ HILNPAFLYS FEKGEGEQLL GPPNPEGDNP ESITSVFITK
VLDPEKQADM LDSLRIYLLQ YATLLVEHAP HHIHDNNKNR NSKLRRLMTF AWPCLLSKAC
VDPACKYSGH LLLAHIIAKF AIHKKIVLQV FHSLLKAHAM EARAIVRQAM AILTPAVPAR
MEDGHQMLTH WTRKIIVEEG HTVPQLVHIL HLIVQHFKVY YPVRHHLVQH MVSAMQRLGF
TPSVTIEQRR LAVDLSEVVI KWELQRIKDQ QPDSDMDPNS SGEGVNSVSS SIKRGLSVDS
AQEVKRFRTA TGAISAVFGR SQSLPGADSL LAKPIDKQHT DTVVNFLIRV ACQVNDNTNT
AGSPGEVLSR RCVNLLKTAL RPDMWPKSEL KLQWFDKLLM TVEQPNQVNY GNICTGLEVL
SFLLTVLQSP AILSSFKPLQ RGIAACMTCG NTKVLRAVHS LLSRLMSIFP TEPSTSSVAS
KYEELECLYA AVGKVIYEGL TNYEKATNAN PSQLFGTLMI LKSACSNNPS YIDRLISVFM
RSLQKMVREH LNPQAASGST EATSAGTSEL VMLSLELVKT RLAVMSMEMR KNFIQAILTS
LIEKSPDAKI LRAVVKIVEE WVKNNSPMAA NQTPTLREKS ILLVKMMTYI EKRFPEDLEL
NAQFLDLVNY VYRDETLSGS ELTAKLEPAF LSGLRCAQPL IRAKFFEVFD NSMKRRVYER
LLYVTCSQNW EAMGNHFWIK QCIELLLAVC EKSTPIGTSC QGAMLPSITN VINLADSHDR
AAFAMVTHVK QEPRERENSE SKEEDVEIDI ELAPGDQTST PKTKELSEKD IGNQLHMLTN
RHDKFLDTLR EVKTGALLSA FVQLCHISTT LAEKTWVQLF PRLWKILSDR QQHALAGEIS
PFLCSGSHQV QRDCQPSALN CFVEAMSQCV PPIPIRPCVL KYLGKTHNLW FRSTLMLEHQ
AFEKGLSLQI KPKQTTEFYE QESITPPQQE ILDSLAELYS LLQEEDMWAG LWQKRCKYSE
TATAIAYEQH GFFEQAQESY EKAMDKAKKE HERSNASPAI FPEYQLWEDH WIRCSKELNQ
WEALTEYGQS KGHINPYLVL ECAWRVSNWT AMKEALVQVE VSCPKEMAWK VNMYRGYLAI
CHPEEQQLSF IERLVEMASS LAIREWRRLP HVVSHVHTPL LQAAQQIIEL QEAAQINAGL
QPTNLGRNNS LHDMKTVVKT WRNRLPIVSD DLSHWSSIFM WRQHHYQGKP TWSGMHSSSI
VTAYENSSQH DPSSNNAMLG VHASASAIIQ YGKIARKQGL VNVALDILSR IHTIPTVPIV
DCFQKIRQQV KCYLQLAGVM GKNECMQGLE VIESTNLKYF TKEMTAEFYA LKGMFLAQIN
KSEEANKAFS AAVQMHDVLV KAWAMWGDYL ENIFVKERQL HLGVSAITCY LHACRHQNES
KSRKYLAKVL WLLSFDDDKN TLADAVDKYC IGVPPIQWLA WIPQLLTCLV GSEGKLLLNL
ISQVGRVYPQ AVYFPIRTLY LTLKIEQRER YKSDPGPIRA TAPMWRCSRI MHMQRELHPT
LLSSLEGIVD QMVWFRENWH EEVLRQLQQG LAKCYSVAFE KSGAVSDAKI TPHTLNFVKK
LVSTFGVGLE NVSNVSTMFS SAASESLARR AQATAQDPVF QKLKGQFTTD FDFSVPGSMK
LHNLISKLKK WIKILEAKTK QLPKFFLIEE KCRFLSNFSA QTAEVEIPGE FLMPKPTHYY
IKIARFMPRV EIVQKHNTAA RRLYIRGHNG KIYPYLVMND ACLTESRREE RVLQLLRLLN
PCLEKRKETT KRHLFFTVPR VVAVSPQMRL VEDNPSSLSL VEIYKQRCAK KGIEHDNPIS
RYYDRLATVQ ARGTQASHQV LRDILKEVQS NMVPRSMLKE WALHTFPNAT DYWTFRKMFT
IQLALIGFAE FVLHLNRLNP EMLQIAQDTG KLNVAYFRFD INDATGDLDA NRPVPFRLTP
NISEFLTTIG VSGPLTASMI AVARCFAQPN FKVDGILKTV LRDEIIAWHK KTQEDTSSPL
SAAGQPENMD SQQLVSLVQK AVTAIMTRLH NLAQFEGGES KVNTLVAAAN SLDNLCRMDP
AWHPWL
//
