ID A0A2K5XSE8_MANLE Unreviewed; 1001 AA.
AC A0A2K5XSE8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Leucine rich repeats and immunoglobulin like domains 1 {ECO:0000313|Ensembl:ENSMLEP00000006249.1};
GN Name=LRIG1 {ECO:0000313|Ensembl:ENSMLEP00000006249.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000006249.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000006249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5XSE8; -.
DR Ensembl; ENSMLET00000028821.1; ENSMLEP00000006249.1; ENSMLEG00000026230.1.
DR GeneTree; ENSGT00940000158502; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF12; KEKKON 5, ISOFORM A; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 706..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 455..554
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 559..596
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 606..692
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 857..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 109533 MW; 6F4FBF9CB700E1D1 CRC64;
DLPAWTRSLN LSYNKLSEID PAGFEDLPNL QEVYLNNNEL TAIPSLGAAS SHVVSLFLQH
NKIRSVEGSQ LKAYLSLEVL DLSSNNITEV RNTCFPHGPP IKELNLAGNR IGTLELGAFD
GLSRSLLTLR LSKNRITQLP VRAFKLPRLT QLDLNRNRIR LIEGLTFQGL NSLEVLKLQR
NNISKLTDGA FWGLSKMHVL HLEYNSLVEV NSGSLYGLTA LHQLHLSNNS IARIHRKGWS
FCQKLHELVL SFNNLTRLDE ESLAELSSLS VLRLSHNSIS HIAEGAFKGL RSLRVLDLDH
NEIAGTIEDT SGAFSGLDSL SKLLLLEPSQ SAGCSSPSQP HMSAGGRTLF GNKIKSVAKR
AFSGLEGLEH LNLGGNAIRS VQFDAFVKMK NLKELHISSD SFLCDCQLKW LPPWLMGRML
QAFVTATCAH PESLKGQSIF SVPPESFVCD DFLKPQIITQ PETTMAMVGK DIRFTCSAAS
SSSSPMTFAW KKDNEVLTNA DMENFVHVHA QDGEVMEYTT ILHLRQVTFG HEGRYQCVIT
NHFGSTYSHK ARLTVNVLPS FTKTPHDITI RTTTMARLEC AATGHPNPQI AWQKDGGTDF
PAAQTPSLAV PLEDRVVSAG ETVALQCKAT GNPPPRITWF KGDRPLSLTE RHHLTPDNQL
LVVQNVVAED AGRYTCELSN TLGTERAHSQ LSVLPAAGCR KDGTTVGIFT IAVVSSIVLT
SLVWVCIIYQ TRKKSEEYSV TNTDETIVPP DVPSYLSSQG TLSDRQETVV RTEGGPQANG
HIESNGVCPR DASHFPEADA HSVACRQPKL CTGYHKEPWK ATEKAEGTPG PQKMEHGGRV
VCSDCNTEVD CYSREQDFHP QPVSRDSVQP NGLEPGGSDQ EHFPHHQCSG TAAGSCSECQ
GSLYPSNHDR MLTAVKKKPM ASLDGKGDSS WTLARLYDPD YAELQPASSL TSGSPERTAA
QHLLVSNGHL PKACDSSPES TPLTGQLPGK QRVPLLLAPK S
//
