ID A0A2K5XTH6_MANLE Unreviewed; 650 AA.
AC A0A2K5XTH6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Melanoma cell adhesion molecule {ECO:0000313|Ensembl:ENSMLEP00000006606.1};
GN Name=MCAM {ECO:0000313|Ensembl:ENSMLEP00000006606.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000006606.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000006606.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A2K5XTH6; -.
DR Ensembl; ENSMLET00000029670.1; ENSMLEP00000006606.1; ENSMLEG00000026928.1.
DR GeneTree; ENSGT00940000155838; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11973:SF18; CELL SURFACE GLYCOPROTEIN MUC18; 1.
DR PANTHER; PTHR11973; CELL SURFACE GLYCOPROTEIN MUC18-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 3.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 563..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..133
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 143..246
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 248..325
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 339..428
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 434..514
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 283..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 71899 MW; 30BF7E3568D6F3B1 CRC64;
YQLPRVGSRV CAECLWSCGG PRLPPPGVPG EAEQPAPELV EVEVGSTALL KCGLSQSQGN
LSHVDWFSVH KEKRIPIFRV RQGQGQSEPG EYQHRLSLQD RGATLALTQV TPHDERIFLC
QGKRPRSQEH RIQLRVYKAP EEPNIQVNAL GIPVDSKEPE EVATCVGRNG YPIPQVIWYK
NGRPLKEEKN RVHIQSSQTV ESSGLYTLQS ILKAQLVKED KDAQFYCELN YRLPSGNHMK
ESREVTVPVF YPTEKVWLEV EPVGMLKEGD RVEIRCLADG NPPPHFSISK QNPSTREAEE
ETTNDNGVLV LEPAQKEHSG LYECQGLDLD TMISLPSEPQ ELLVNYVSDV RVSPAAPERQ
EGSSLTLICE AESSQDLEFQ WLREETGQVL ERGPVLQLHD LKREAGGGYR CVASVPSIPG
LNRTQLVNVA VFGPPWMAFK ERKVWVKENM MLNLSCEASG HPRPTISWNV NGTASEQDQD
PQRVLSTLNV LVTPELLETG VECTASNDLG KNTSVLFLEL VNLTTLTPDS NTTTGLSTST
ASLGCARASF LPQRKLPEPE SQGVVIVAVI VCILVLAVLG AVLYFLYKKG KLPCGRSGKQ
EITLPPSRKS EFVVEVKSDK LPEEMGLLQG SSGDKRAPGD QGEKYIDLRH
//
