ID   A0A2K5XUM9_MANLE        Unreviewed;      1096 AA.
AC   A0A2K5XUM9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=BUB1 mitotic checkpoint serine/threonine kinase {ECO:0000313|Ensembl:ENSMLEP00000007002.1};
GN   Name=BUB1 {ECO:0000313|Ensembl:ENSMLEP00000007002.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000007002.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000007002.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5XUM9; -.
DR   STRING; 9568.ENSMLEP00000007002; -.
DR   Ensembl; ENSMLET00000030275.1; ENSMLEP00000007002.1; ENSMLEG00000027284.1.
DR   GeneTree; ENSGT00940000157865; -.
DR   OMA; NCEKGVG; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000940; C:outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140995; F:histone H2A kinase activity; IEA:Ensembl.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:Ensembl.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:Ensembl.
DR   GO; GO:2000720; P:positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric; IEA:Ensembl.
DR   Gene3D; 1.25.40.430; -; 1.
DR   Gene3D; 6.10.130.20; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015661; Bub1/Mad3.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR013212; Mad3/Bub1_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   PANTHER; PTHR14030:SF26; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1; 1.
DR   Pfam; PF08311; Mad3_BUB1_I; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00777; Mad3_BUB1_I; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51489; BUB1_N; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          11..182
FT                   /note="BUB1 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51489"
FT   DOMAIN          787..1096
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          538..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         821
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1096 AA;  123905 MW;  486931486CC85A50 CRC64;
     MDTPENVLQM LEAHMQSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE HLMKEFLDKK
     KYHNDPRFIN YCLKFAEYNS DLHQFFEFLY NRGIGTLSSL LYITWAGHLE AQGELQHASA
     VLQRGIQNQA EPRQLLQQQY RLFQTRRTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN
     NMACISKNQG SELSGVVSSA CDKESNMEQR VIMISKSEYS VHSSLASKAD VEQVVMYCKE
     KLIRGESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL
     HQVVETSHEE LPASQERSEV NPACMGPSVG SQQELRAPCL PVTYQQTPVN MEKNPREAPP
     VVPPLANAIS AALVSPASSQ SIAPPVPLKA QTVTDSVFAV ASKDAGCVNK STHEFKPQSG
     AEIKEGCETH KVANTSSFHT TPNTSLGMVQ ATPSKVQPSP TVHTKEALGF IMNMFQAPTL
     PDISDDKDEW QSLDQNEDAF EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL
     PQPKNKPTGA RTFGERSVSR LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF
     TSAAQLASTP FHKLPVESLQ ILEDKENVIA KQCTHVTLDS CEENMVVPPK DRKFSPIQEK
     SPEQAFSSHM YSASLLRLSQ SAAGGVPTCE AELGVEACGL TDTDAATAED PPDAMAGLQA
     ERMQMSSLGN ADAPNFIVGN PWDDKLIFKL LSGLSKPVSS YPNTFEWQCK LPAIKPKTEF
     QLGSKLVNVH HLLGEGAFAQ VYEATQGDVN DAKNKQKFVL KVQKPANPWE FYIGTQLMER
     LKPTMQHMFM KFYSAHFFQN GISIHFYDEH MNLKCIFGLY LARTFVNAIN LYKNTPEKVM
     PQGLVISFAM RMLYMIEQVH DCEIIHGDIK PDNFILGNGF LEQDDEDDLS AGLALIDLGQ
     SIDMKLFPKG TIFTGKCETS GFQCVEMLSN KPWNYQIDYF GVAATVYCML FGTYMKVKNE
     GGECKPEGLF RRLPHLDMWN EFFHIMLNIP DSHHLPSLDL LRQKLKKVFQ QHYTNKIRAL
     RNRLIVLLLE YKRSRK
//