ID A0A2K5XUQ3_MANLE Unreviewed; 339 AA.
AC A0A2K5XUQ3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Neutrophil cytosolic factor 4 {ECO:0000313|Ensembl:ENSMLEP00000007015.1};
GN Name=NCF4 {ECO:0000313|Ensembl:ENSMLEP00000007015.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000007015.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000007015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011834323.1; XM_011978933.1.
DR AlphaFoldDB; A0A2K5XUQ3; -.
DR Ensembl; ENSMLET00000030289.1; ENSMLEP00000007015.1; ENSMLEG00000027451.1.
DR GeneID; 105538913; -.
DR CTD; 4689; -.
DR GeneTree; ENSGT00510000048561; -.
DR OMA; KLHVTQQ; -.
DR OrthoDB; 2997622at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:InterPro.
DR GO; GO:0045730; P:respiratory burst; IEA:InterPro.
DR CDD; cd06399; PB1_P40; 1.
DR CDD; cd06882; PX_p40phox; 1.
DR CDD; cd11869; SH3_p40phox; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000919; p40phox.
DR InterPro; IPR035541; p40phox_SH3.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034853; PB1_P40.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR034912; PX_p40phox.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF20; NEUTROPHIL CYTOSOL FACTOR 4; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00497; P40PHOX.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 19..140
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 170..229
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 237..329
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
SQ SEQUENCE 339 AA; 39092 MW; 60337BECED9C6F0C CRC64;
MAVAQQLRAE SDFEQLPDDV AISANIADIE EKRGFTSHFV FVIEVKTKGG SKYLIYRRYR
QFYALQSKLE ERFGPDSKSS APACTLPTLP AKVYMGVKQE IAEMRIPALN AYMKSLLSLP
VWVLMDEDVR IFFYQSPYDS EQVPQALRRL RPRTRKVKSV SPQGNSVDRM AAPRAEALFD
FTGNSKLELN FKAGDVIFLL SRINKDWLEG TVRGATGIFP LSFVKILKDF PEEDDPTNWL
RCYYYEDTIS TVKDIAVEED LSSTPLFKDL LELTRREFQR EDIALNYRDA EGDLVRLLSD
EDVVLMVRKA RGLPSQKRLF PWKLHITQKD NYRVYNTTP
//
