ID   A0A2K5XVI3_MANLE        Unreviewed;       486 AA.
AC   A0A2K5XVI3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Acid sensing ion channel subunit 2 {ECO:0000313|Ensembl:ENSMLEP00000007318.1};
GN   Name=ASIC2 {ECO:0000313|Ensembl:ENSMLEP00000007318.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000007318.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000007318.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_011848261.1; XM_011992871.1.
DR   AlphaFoldDB; A0A2K5XVI3; -.
DR   STRING; 9568.ENSMLEP00000007318; -.
DR   Ensembl; ENSMLET00000030624.1; ENSMLEP00000007318.1; ENSMLEG00000027675.1.
DR   GeneID; 105548704; -.
DR   KEGG; mleu:105548704; -.
DR   GeneTree; ENSGT00940000154991; -.
DR   OMA; AMIRKGC; -.
DR   OrthoDB; 3415680at2759; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0050915; P:sensory perception of sour taste; IEA:Ensembl.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF128; ACID-SENSING ION CHANNEL 2; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022461}.
SQ   SEQUENCE   486 AA;  55118 MW;  C48B5B6039D1A1D7 CRC64;
     AAGGSFQRRA LWVLAFCTSL GLLLSWSSNR LLYWLSFPSH TRVHREWSRQ LPFPAVTVCN
     NNPLRFPRLS KGDLYYAGHW LGLLLPNRTA RPLVSELLRG DEPRRQWFRK LADFRLFLPP
     RHFEGISAAF MDRLGHQLED MLLSCKYRGE LCGPHNFSSV FTKYGKCYMF NSGEDGKPLL
     TTVKGGTGNG LEIMLDIQQD EYLPIWGETE ETTFEAGVKV QIHSQSEPPF IQELGFGVAP
     GFQTFVATQE QRLTYLPPPW GECRSSEMGL DFFPVYSITA CRIDCETRYI VENCNCRMVH
     MPGDAPFCTP EQHKECAEPA LGLLAEKDSN YCLCRTPCNL TRYNKELSMV KIPSKTSAKY
     LEKKFNKSEK YISENILVLD IFFEALNYET IEQKKAYEVA ALLGDIGGQM GLFIGASILT
     ILELFDYIYE LIKEKLLDLL GKEEDDGSHD ENVSTCDTMP NHSETISHTV NVPLQTALGT
     LEEIAC
//