ID   A0A2K5XX23_MANLE        Unreviewed;      1540 AA.
AC   A0A2K5XX23;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSMLEP00000007830.1};
GN   Name=IQGAP2 {ECO:0000313|Ensembl:ENSMLEP00000007830.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000007830.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000007830.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSMLET00000031184.1; ENSMLEP00000007830.1; ENSMLEG00000027862.1.
DR   GeneTree; ENSGT00950000183076; -.
DR   Proteomes; UP000233140; Unplaced.
DR   Gene3D; 1.20.5.190; -; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 2.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 3.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 3.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          6..121
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          882..1115
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   COILED          130..157
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1376..1403
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1540 AA;  175896 MW;  77DD057B8A1A632C CRC64;
     DGVSLCRPGW SAVVWMEVCL VEELPPTTEL EEGLRNGVYL AKLAKFFAPK MVSEKKIYDV
     EQTRYKKSGL HFRHTDNTVQ WLRAMESIGL PKIFYPETTD VYDRKNIPRM IYCIHALSLY
     LFKLGIAPQI QDLLGKVDFT EEEISNMRKE LEKYGIQMPS FSKIGGILAN ELSVDEAALH
     AAVIAINEAV EKGVAEQTIV TLRNPNAVLT LVDDNLAPEY QKELWDAKKK KEENARLKNS
     CISEEERDAY EELLTQAEIQ GNINKVNRQA AVDHINAVIP EGDPENTLLA LKKPEAQLPA
     VYPFAAAMYQ NELFNLQKQN AMNYLAHEEL LIAVEMLSAV ALLNQALESN DLVSVQNQLR
     SPTIGLNNLD KAYVERYANT LLSVKLEVLS QGQDNLSWNE IQNCIDMVNA QIQEENDRVV
     AVGYINEAID EGNPLRTLET LLLPTANISD VDPAHAQHYQ DVLYRAKSQK LGDSESVSKV
     LWLDEIQQAV DEANVDEDRA KQWVTLVVDV NQCLEGKKSS DILSVLKSST SNANDIIPEC
     ADKYYDALVK AKELKSERVS SEGSWLKLNL NEKYDYCYNI DSKEGSWVIP ESCLYKESWL
     TGKEIEDIIE EVTVGYIREN IWSASEEMLL RFQATSSGPI LRDEFEARKS FLHEQEENVV
     KIQAFWKGCK QRKVYMHRRQ TFIDNTDSIV KIQSWFRMAT ARKSYLSRLQ YFRDHNNEIV
     KIQSLLRANK ARDDYKTLVG SENPPLTVIR KFVYLLDQSD LDFQEELEVA RLREEVVTKI
     RANQQLEKDL NLMDIKIGLL VKNRITLEDV ISHSKKLNKK KGGEMEILNN TDNQGIKSLS
     KERRKTLETY QQLFYLLQTN PLYLAKLIFQ MPQNKSTKFM DTVIFTLYNY ASNQREEYLL
     LKLFKTALEE EIKSKVDQVQ DIVTGNPTVI KMVVSFNRGA RGQNTLRQLL AAVVKEIIED
     KSLIINTNPV EVYKAWVNQL ETQTGEASKL PYDVTTEQAL TYPEVKNKLE ASIENLRRVT
     DKVLNSIISS LDLLPYGLRY IAKVLKNSIH EKFPDATEDE LLKIVGNLLY YRYMNPAIVA
     PDGFDIIDMT AGGQINSDQR RNLGSVAKVL QHAASNKLFE GENEHLSSMN NYLSETYQEF
     RKYFKEACNV PEPEEKFNMD KYTDLVTVSK PVIYISIEEI ISTHSLLLEH QDAIAPEKND
     LLSELLGSLG EVPTVESFLG EGAVDPNDPN KANTLSQLSK TEISLVLASK YDIEDGEAID
     SRSLMIKTKK LIIDVIRNQP GNTLTEILET PATAQQEADH ATDMVSRAMI DSRTPEEMKH
     SQSMIEDAQL PLEQKKRKIQ RNLRTLEQTG HVSSKNKYQD ILNEIAKDIR NQRIYRKLRK
     AELAKLQQTL NALNKKAAFY EEQINYYDTY IKTCLDNLKR KNTRRSIKLD GKGEPKGTKR
     AKPVKYTAAK LHEKGVLLDI DDLQTNQFKN VTFDIIATED VGIFDVRSKF LGVEMEKVQL
     NIQDLLQMQY EGVAVMKMFD KVKVNVNLLI YLLNKKFYGK
//