ID A0A2K5XXD8_MANLE Unreviewed; 598 AA.
AC A0A2K5XXD8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Cadherin-5 {ECO:0000256|ARBA:ARBA00021701};
DE AltName: Full=Vascular endothelial cadherin {ECO:0000256|ARBA:ARBA00030559};
GN Name=CDH5 {ECO:0000313|Ensembl:ENSMLEP00000007974.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000007974.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000007974.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A2K5XXD8; -.
DR Ensembl; ENSMLET00000031336.1; ENSMLEP00000007974.1; ENSMLEG00000028105.1.
DR GeneTree; ENSGT00940000160587; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 4.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF89; CADHERIN-5; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 3.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 4.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..598
FT /note="Cadherin-5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014391707"
FT DOMAIN 58..152
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 153..259
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 260..373
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 392..474
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 598 AA; 66679 MW; 10CCD7025BD8007A CRC64;
MQRLMMLVAT SGACLGLLAA AAAAAAAGAN PAQRDTPSLL PTHRRQKRDW IWNQMHIDEE
KNTSLPHHVG KIKSSVSRKN AKYLLKGEFV DKVFRVDAET GDVFAIERLD RENISEYHLT
AVIVDKDTGE NLETPSSFTI KVHDVNDNWP VFTHRLFNAS VPESSAVGTS VISVTAVDAD
DPTVGDHASV MYQILKGKEY FAIDNSGRIV TITKSLDREK QARYEIVVEA RDAQGLRGDS
GTATVLVTLQ DINDNFPFFT QTKYTFVVPE DTRVGTSVGS LFVEDPDEPQ NRMTKYSILR
GDYQDAFTIE TNPTHNEGII KPMKPLDYEY IQQYSFIVEA TDPTIDLRYL SPPAGNRAQV
IINITDVDEP PIFQQPFYHF QLKENQKKPL IDKDITPRNV KFKFTLNTEN NFTLTDNHDN
TANITVKYGQ FDREHTKVHF LPVVISDNGM PSRTGTSTLT VAVCKCNEQG EFTFCEDMAA
QVGVSIQAVV AILLSILTIT GQCWAVGGRG LKVLREGEMA AMIEVKKDEA DHDGDGPPYD
TLHIYGYEGS ESIAESLSSL GTDSSDSDVD YDFLNDWGPR FKMLAELYGS DPREELLY
//