ID A0A2K5XXJ3_MANLE Unreviewed; 758 AA.
AC A0A2K5XXJ3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A3 {ECO:0000313|Ensembl:ENSMLEP00000008029.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000008029.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000008029.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC role in the chloride and bicarbonate homeostasis during sperm
CC epididymal maturation and capacitation.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_011841756.1; XM_011986366.1.
DR AlphaFoldDB; A0A2K5XXJ3; -.
DR STRING; 9568.ENSMLEP00000008029; -.
DR Ensembl; ENSMLET00000031398.1; ENSMLEP00000008029.1; ENSMLEG00000028170.1.
DR GeneID; 105544090; -.
DR KEGG; mleu:105544090; -.
DR CTD; 1811; -.
DR GeneTree; ENSGT01070000253775; -.
DR OMA; ALYWIPK; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
DR GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 104..121
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 202..224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 253..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 282..301
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 369..386
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 465..491
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 519..714
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 758 AA; 84133 MW; 348E661ABB0C589E CRC64;
MIEPFGNQYI VARPVYSTNA FEENHKKRDR HHKTFLDHLR VCFSCSPQKA KRIVLSLFPI
ASWLPGYRLK EWLLSDIVSG ISTGIVSVLQ GLAFALLVTI PPGYGLYAAF FSTIIYLFFG
TSKHISAGPF PILSMMVGAA TVRLAQNFPG NTGSSNNSTS NSSSLDDYKV TVAASVTVLS
GVIQLALGFL RIGFVVIYLS ESLISGFTTA AAVHVLVSQL KFIFQLTVPS HEDPCSIFKV
LYSVFSQIEK TNIADLVTAL IVLLVVSIFK EINQRFKDKL PVPIPIEFIV TVIATGVSYG
FDFQTRFNVS VVGKMNPGFE PPTAPNVMVF QETIGDCFAI AMVGFAVAFS VASVYSLKHD
YPLDGNQELI ALGLGNIVCG AFRGFAGSTA LSRSAVQEST GGKTQIAGLI SAIIVLIVIL
AIGFLLEPLQ RSVLAALALG NLKGMLMQFA EIYRLWRKDK YDCLIWVTTC VFTIVLGLGL
GLAASVAFQL LTIVFRTQFP KCSTLANIGR SNIYKNKKDY YDMYELKGVK IFRCPSPIYF
ANIGFFRQKL IDAVGFSPLR ILRKRNKALR KIRKLQKQGL LQVTPKGFIC TVDTIKDSDE
ELDNNQIQVL DKPIDTTDLP FQIDWNDQLP LNIEVPKISL HSLILDFSAV SFLDVSSMRG
LKSILQEFIR IKVDVYIVGV DDDFIEKLNR YEFFDGEVKT SILFLTIHDA VLHISMKKDY
STSKFKPSQE KDGKIDFTIN TNGGLRNREY QVPGETKF
//