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Database: UniProt
Entry: A0A2K5XXJ3_MANLE
LinkDB: A0A2K5XXJ3_MANLE
Original site: A0A2K5XXJ3_MANLE 
ID   A0A2K5XXJ3_MANLE        Unreviewed;       758 AA.
AC   A0A2K5XXJ3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A3 {ECO:0000313|Ensembl:ENSMLEP00000008029.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000008029.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000008029.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR   RefSeq; XP_011841756.1; XM_011986366.1.
DR   AlphaFoldDB; A0A2K5XXJ3; -.
DR   STRING; 9568.ENSMLEP00000008029; -.
DR   Ensembl; ENSMLET00000031398.1; ENSMLEP00000008029.1; ENSMLEG00000028170.1.
DR   GeneID; 105544090; -.
DR   KEGG; mleu:105544090; -.
DR   CTD; 1811; -.
DR   GeneTree; ENSGT01070000253775; -.
DR   OMA; ALYWIPK; -.
DR   OrthoDB; 1067648at2759; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR   GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR   GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
DR   GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        77..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        104..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        168..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        202..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        253..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        282..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        338..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        369..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        465..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          519..714
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   758 AA;  84133 MW;  348E661ABB0C589E CRC64;
     MIEPFGNQYI VARPVYSTNA FEENHKKRDR HHKTFLDHLR VCFSCSPQKA KRIVLSLFPI
     ASWLPGYRLK EWLLSDIVSG ISTGIVSVLQ GLAFALLVTI PPGYGLYAAF FSTIIYLFFG
     TSKHISAGPF PILSMMVGAA TVRLAQNFPG NTGSSNNSTS NSSSLDDYKV TVAASVTVLS
     GVIQLALGFL RIGFVVIYLS ESLISGFTTA AAVHVLVSQL KFIFQLTVPS HEDPCSIFKV
     LYSVFSQIEK TNIADLVTAL IVLLVVSIFK EINQRFKDKL PVPIPIEFIV TVIATGVSYG
     FDFQTRFNVS VVGKMNPGFE PPTAPNVMVF QETIGDCFAI AMVGFAVAFS VASVYSLKHD
     YPLDGNQELI ALGLGNIVCG AFRGFAGSTA LSRSAVQEST GGKTQIAGLI SAIIVLIVIL
     AIGFLLEPLQ RSVLAALALG NLKGMLMQFA EIYRLWRKDK YDCLIWVTTC VFTIVLGLGL
     GLAASVAFQL LTIVFRTQFP KCSTLANIGR SNIYKNKKDY YDMYELKGVK IFRCPSPIYF
     ANIGFFRQKL IDAVGFSPLR ILRKRNKALR KIRKLQKQGL LQVTPKGFIC TVDTIKDSDE
     ELDNNQIQVL DKPIDTTDLP FQIDWNDQLP LNIEVPKISL HSLILDFSAV SFLDVSSMRG
     LKSILQEFIR IKVDVYIVGV DDDFIEKLNR YEFFDGEVKT SILFLTIHDA VLHISMKKDY
     STSKFKPSQE KDGKIDFTIN TNGGLRNREY QVPGETKF
//
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