ID A0A2K5XZC8_MANLE Unreviewed; 353 AA.
AC A0A2K5XZC8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Platelet-derived growth factor D {ECO:0000256|ARBA:ARBA00018876};
GN Name=PDGFD {ECO:0000313|Ensembl:ENSMLEP00000008673.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000008673.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000008673.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers,
CC and with heterodimers formed by PDGFRA and PDGFRB.
CC {ECO:0000256|ARBA:ARBA00026039}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR RefSeq; XP_011839802.1; XM_011984412.1.
DR AlphaFoldDB; A0A2K5XZC8; -.
DR STRING; 9568.ENSMLEP00000008673; -.
DR Ensembl; ENSMLET00000032068.1; ENSMLEP00000008673.1; ENSMLEG00000028545.1.
DR GeneID; 105542755; -.
DR KEGG; mleu:105542755; -.
DR CTD; 80310; -.
DR GeneTree; ENSGT00940000159575; -.
DR OMA; HHETCEC; -.
DR OrthoDB; 3908391at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF4; PLATELET-DERIVED GROWTH FACTOR D; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00042; CUB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 35..153
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 242..345
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 353 AA; 40746 MW; CA105679ED29B016 CRC64;
CRDTSATPQS ASIKALRNAN LRRDESNHLT DLYRRDETIQ VKGNGFVQSP RFPNSYPRNL
LLTWRLHSQE NTRIQLVFDN QFGLEEAEND ICRYDFVEVE DISETSTIIR GRWCGHKEVP
PRIKSRTNQI KITFKSDDYF VAKPGFKIYY SLVEDFQPAA ASETNWESVT SSISGVSYNS
PSVTDPTLIA DALDKKIAEF DTVEDLLKYF NPESWQEDLE NMYLNTPRYR GRSYHDRKSK
VDLDRLNDDA KRYSCTPRNY SVNIREELKL ANVVFFPRCL LVQRCGGNCG CGTVNWRSCT
CNSGKTVKKY HEVLQFEPGH IKRKGRAKAM ALVDIQLDHH ERCDCICSSR PPR
//
