ID   A0A2K5Y165_MANLE        Unreviewed;       404 AA.
AC   A0A2K5Y165;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Serpin family F member 2 {ECO:0000313|Ensembl:ENSMLEP00000009307.1};
GN   Name=SERPINF2 {ECO:0000313|Ensembl:ENSMLEP00000009307.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000009307.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000009307.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411}.
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DR   AlphaFoldDB; A0A2K5Y165; -.
DR   STRING; 9568.ENSMLEP00000009307; -.
DR   Ensembl; ENSMLET00000032706.1; ENSMLEP00000009307.1; ENSMLEG00000028849.1.
DR   GeneTree; ENSGT00940000158386; -.
DR   OMA; HAYPLRW; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005577; C:fibrinogen complex; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
DR   GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR   GO; GO:0002034; P:maintenance of blood vessel diameter homeostasis by renin-angiotensin; IEA:Ensembl.
DR   GO; GO:0051918; P:negative regulation of fibrinolysis; IEA:Ensembl.
DR   GO; GO:0010757; P:negative regulation of plasminogen activation; IEA:Ensembl.
DR   GO; GO:0045597; P:positive regulation of cell differentiation; IEA:Ensembl.
DR   GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0071636; P:positive regulation of transforming growth factor beta production; IEA:Ensembl.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461:SF20; ALPHA-2-ANTIPLASMIN; 1.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          31..349
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
FT   REGION          350..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..375
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   404 AA;  45831 MW;  3E9C2127680EA4A0 CRC64;
     LYCFPLCWRV SLWETEAQRG KATCHPTCQP QRGESRAQNH TLQRLQQVLH AGSGPCLPHL
     LSRLCQNLGP GAFRLAARMY LQKGFPIKED FLEQSERLFG AKPVSLTGKQ EDDLANINQW
     VKEATEGKIP EFLSELPEDT VLLLLNAIHF QGFWRSKFDP SLTRRDSFHL DEQFTVPVEM
     MQARTYPLRW FMLEQPEIQV AHFPFKNNMS FVVLVPTHFE WNVSQVLANL SWDTLHPPSV
     WERPTKVRLP KLYLKHQMDL VATLSRLGLQ ELFQAPDLRG ISEQSLVVSG VQHQSTLELS
     EVGVEAAAAT SIAMSRMSLS SFSVNRPFLF FIFEDTTGLP LFVGSVRNPN PSAPRELKEQ
     QDSPGDKDFL HSLKAGPRGD KLFSPDLKLA PPLEEDYSEL GSPK
//