ID A0A2K5Y1T0_MANLE Unreviewed; 256 AA.
AC A0A2K5Y1T0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Coiled-coil-helix-coiled-coil-helix domain containing 6 {ECO:0000313|Ensembl:ENSMLEP00000009509.1};
GN Name=CHCHD6 {ECO:0000313|Ensembl:ENSMLEP00000009509.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000009509.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000009509.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane.
CC {ECO:0000256|ARBA:ARBA00002689}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00034476}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family. Metazoan
CC Mic25 subfamily. {ECO:0000256|ARBA:ARBA00034480}.
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DR RefSeq; XP_011826892.1; XM_011971502.1.
DR AlphaFoldDB; A0A2K5Y1T0; -.
DR STRING; 9568.ENSMLEP00000009509; -.
DR Ensembl; ENSMLET00000032910.1; ENSMLEP00000009509.1; ENSMLEG00000028928.1.
DR GeneID; 105533154; -.
DR KEGG; mleu:105533154; -.
DR CTD; 84303; -.
DR GeneTree; ENSGT00390000000903; -.
DR OrthoDB; 3383910at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0061617; C:MICOS complex; IEA:Ensembl.
DR GO; GO:0042407; P:cristae formation; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR InterPro; IPR007964; MIC19/MIC25.
DR InterPro; IPR042860; MIC25.
DR PANTHER; PTHR47609; MICOS COMPLEX SUBUNIT MIC25; 1.
DR PANTHER; PTHR47609:SF1; MICOS COMPLEX SUBUNIT MIC25; 1.
DR Pfam; PF05300; MIC19_MIC25; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT REGION 31..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 28347 MW; A69FC608EAE9AC39 CRC64;
MGSTESSEGR RVSFGVDEEE RVRVLQGVRL SENVVNRMKE PSSPPPAPAP STLGLQDGNL
RAPHKESTLP RSGSSGGQQI SGAKEDVKRC EQEHAAVQDK LFQVAKTERE AATKHSKASV
PVGEGSISHE EQKSVRLQAR ELESREAELR RRDTFYKEQL GRIERKNAEM YKLSSQQFHE
AASKMESTIK PRRVEPICSG LQAQILHCYR DRPHEVLLCS DLVKAYQRCV SAAHKVRPCL
PPRFPGGLGG RGGTSV
//
