ID A0A2K5Y3P5_MANLE Unreviewed; 883 AA.
AC A0A2K5Y3P5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Leucine rich repeat containing G protein-coupled receptor 5 {ECO:0000313|Ensembl:ENSMLEP00000010178.1};
GN Name=LGR5 {ECO:0000313|Ensembl:ENSMLEP00000010178.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000010178.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000010178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_011833903.1; XM_011978513.1.
DR AlphaFoldDB; A0A2K5Y3P5; -.
DR Ensembl; ENSMLET00000033583.1; ENSMLEP00000010178.1; ENSMLEG00000029248.1.
DR GeneID; 105538617; -.
DR CTD; 8549; -.
DR GeneTree; ENSGT00940000160214; -.
DR OrthoDB; 4257264at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
DR CDD; cd15363; 7tmA_LGR5; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002131; Gphrmn_rcpt_fam.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF71; LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01462; LRRNT; 1.
DR PRINTS; PR00373; GLYCHORMONER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..883
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014374024"
FT TRANSMEM 534..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 550..796
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 883 AA; 97321 MW; F9744D99A730BBF2 CRC64;
MDTSRLGVLL SLPVLLQLAA GSSSPRSGAL LRGCPTHCHC EPDGRMLLRV DCSDLGLSEL
PSNLSVFTSY LDLSMNNISQ LLPNPLPSLR FLEELRLAGN ALTYIPKGAF TGLYSLKVLM
LQNNQLRQVP TEALQNLRSL QSLRLDANHI SYVPPSCFSG LHSLRHLWLD DNALTEIPVQ
AFRSLSALQA MTLALNKIHH IPDYAFGNLS SLVVLHLHNN RIHSLGKKCF DGLHSLETLD
LNYNNLDEFP TAIRTLSNLK ELHFYDNPIQ FVGRSAFQHL PELRTLTLNG ASQITEFPDL
TGTANLESLT LTGAQISSLP QTVCNQLPNL QVLDLSYNLL EDLPSFSVCQ KLQKIDLRHN
EIYEIKVDTF QQLLSLRSLN LAWNKIAIIH PNAFTTLPSL IKLDLSSNLL SSFPVTGLHG
LTHLKLTGNH ALQSLISSEN FPELKIIEMP YAYQCCAFGV CENAYKISNQ WNKGDNSSMD
DLHKKDAGMF QVQDERDLED FLLDFEEDLK ALHSVQCSPS PGPFKPCEHL LDGWLIRIGV
WTIAVLALTC NALVTSTVFR SPLYISPIKL LIGVIAVVNM LTGVSSAVLA GVDAFTFGSF
ARHGAWWENG VGCQVIGFLS IFASESSVFL LTLAALERGF SVKCSAKFET KAPFSSLKVI
ILLCALLALT MAAVPLLGGS EYGASPLCLP LPFGEPSTTG YMVALILLNS LCFLMMTIAY
TKLYCNLDKG DLENIWDCSM VKHIALLLFT NCILYCPVAF LSFSSLLNLT FISPEVIKFI
LLVIVPLPAC LNPLLYILFN PHFKEDLVSL GKQTYFWTRS KHPSLMSINS DDVEKQSCDS
TQALVTFTSS SIAYDLPPSS VPSPAYPVTE SCHLSSVAFV PCL
//
