ID A0A2K5Y5L9_MANLE Unreviewed; 446 AA.
AC A0A2K5Y5L9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Caspase 5 {ECO:0000313|Ensembl:ENSMLEP00000010853.1};
GN Name=CASP5 {ECO:0000313|Ensembl:ENSMLEP00000010853.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000010853.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000010853.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR AlphaFoldDB; A0A2K5Y5L9; -.
DR STRING; 9568.ENSMLEP00000010853; -.
DR Ensembl; ENSMLET00000034271.1; ENSMLEP00000010853.1; ENSMLEG00000029602.1.
DR GeneTree; ENSGT00940000161497; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0072558; C:NLRP1 inflammasome complex; IEA:Ensembl.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProt.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR002398; Pept_C14.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR47901:SF3; CASPASE-1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PIRSF; PIRSF038001; Caspase_ICE; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00114; CARD; 1.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 68..150
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 203..331
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 359..444
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 446 AA; 51309 MW; C5831855E975763A CRC64;
MAAMPIFEGV FIFPTEDSGK QNLHKNLEAL FKRALRSTSD NFVTNHMPKD NMAEQTSMQI
LSTTNQKSTS VKRDNRKKEI LKVLEYLGKD MLHGVFNHLA KHDVLTLKEE EKKKYYDAKI
EDKALILVDS VRKNRVAHQR FTQTLLNMDQ RITSVKPLLQ IEAGPPESAE STNTLILCPH
EEFLRRCKEN HDEIYPIKKR EDRKRLALII CNTEFDHLPP RTGAHFDILG MKGLLQGLGY
NVVDKTKLTA REMESELRAF ARRPEHKSSD STFLVLMSHG ILEGICGTAH DEKNPDVLLY
DTVFQIFNNR NCLSLKDKPK VIIVQACRGE GRGEHWVRDS PASLAVISSQ SPENLEEDSV
CRVHVEKDFI AFCSSTPHNM SWRDCTKGSI FIMELITCFQ KYSWCYHLMK IFQKVQKSFE
IPMAKAQMPT IERVSLTRDF YLFPGN
//