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Database: UniProt
Entry: A0A2K5Y5L9_MANLE
LinkDB: A0A2K5Y5L9_MANLE
Original site: A0A2K5Y5L9_MANLE 
ID   A0A2K5Y5L9_MANLE        Unreviewed;       446 AA.
AC   A0A2K5Y5L9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Caspase 5 {ECO:0000313|Ensembl:ENSMLEP00000010853.1};
GN   Name=CASP5 {ECO:0000313|Ensembl:ENSMLEP00000010853.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000010853.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000010853.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   AlphaFoldDB; A0A2K5Y5L9; -.
DR   STRING; 9568.ENSMLEP00000010853; -.
DR   Ensembl; ENSMLET00000034271.1; ENSMLEP00000010853.1; ENSMLEG00000029602.1.
DR   GeneTree; ENSGT00940000161497; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0072558; C:NLRP1 inflammasome complex; IEA:Ensembl.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProt.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd00032; CASc; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR016129; Caspase_his_AS.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR002398; Pept_C14.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR   PANTHER; PTHR47901:SF3; CASPASE-1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PIRSF; PIRSF038001; Caspase_ICE; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00114; CARD; 1.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS01121; CASPASE_HIS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          68..150
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   DOMAIN          203..331
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          359..444
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
SQ   SEQUENCE   446 AA;  51309 MW;  C5831855E975763A CRC64;
     MAAMPIFEGV FIFPTEDSGK QNLHKNLEAL FKRALRSTSD NFVTNHMPKD NMAEQTSMQI
     LSTTNQKSTS VKRDNRKKEI LKVLEYLGKD MLHGVFNHLA KHDVLTLKEE EKKKYYDAKI
     EDKALILVDS VRKNRVAHQR FTQTLLNMDQ RITSVKPLLQ IEAGPPESAE STNTLILCPH
     EEFLRRCKEN HDEIYPIKKR EDRKRLALII CNTEFDHLPP RTGAHFDILG MKGLLQGLGY
     NVVDKTKLTA REMESELRAF ARRPEHKSSD STFLVLMSHG ILEGICGTAH DEKNPDVLLY
     DTVFQIFNNR NCLSLKDKPK VIIVQACRGE GRGEHWVRDS PASLAVISSQ SPENLEEDSV
     CRVHVEKDFI AFCSSTPHNM SWRDCTKGSI FIMELITCFQ KYSWCYHLMK IFQKVQKSFE
     IPMAKAQMPT IERVSLTRDF YLFPGN
//
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