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Database: UniProt
Entry: A0A2K5Y6C0_MANLE
LinkDB: A0A2K5Y6C0_MANLE
Original site: A0A2K5Y6C0_MANLE 
ID   A0A2K5Y6C0_MANLE        Unreviewed;       574 AA.
AC   A0A2K5Y6C0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE            EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN   Name=ACSS1 {ECO:0000313|Ensembl:ENSMLEP00000011107.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000011107.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000011107.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:456215; EC=6.2.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU361147};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|RuleBase:RU361147}.
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DR   AlphaFoldDB; A0A2K5Y6C0; -.
DR   Ensembl; ENSMLET00000034529.1; ENSMLEP00000011107.1; ENSMLEG00000029721.1.
DR   GeneTree; ENSGT00940000158550; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF110; ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU361147};
KW   Ligase {ECO:0000256|RuleBase:RU361147};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361147};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          57..113
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          115..507
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   574 AA;  62583 MW;  0B0C2DA708BC86D9 CRC64;
     MAARSLGRGV GRLLGSLRGL SGQPARPLCR VSAQRRAASG PSGSAPAVAA ASQPGSYPAL
     SAQAAREPAA FWGPLARDTL LWDTPYHTVW DCDFSTGKIG WFLGGQLNVS VNCLDQHVWK
     SPESVALIWE RDEPGTEVRI TYRELLETTC RLANTLKRHG VCRGDCVAIY MPVSPLAVAA
     MLACARIGAV HTVVFAGFSA ASLAGRINDA KCKVVITFNQ GLRGGRVMEL KKIVDEAVKH
     CPTVQRVLVA HRTDNKVHMG DLDIPLEQEM AKEDPVCAPE SMGSEDVLFM LYTSGSTGMP
     KGIVHTQAGY LLYAALTHKL VFDHRPGDIF GCVADIGWIT GHSYVVYGPL CNGATSVLFE
     STPVYPNAGR YWETVERLKI NQFYGAPTAV RLLLKYGDAW VKKYDRSSLR TLGSVGEPIN
     CEAWEWLHRV VGDSRCTLVD TWWQTETGGI CIAPRPSEEG AEILPGMAMR PFFGIVPVLM
     DEKGSVVEGS NVSGALCISQ AWPGMARTIY GDHQRFVDAY FKAYPGYYFT GDGAHRTEGG
     YYQITGRMDD VINTLQIGGL FREAIRNSGD LLEH
//
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