ID A0A2K5Y827_MANLE Unreviewed; 248 AA.
AC A0A2K5Y827;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=14-3-3 protein theta {ECO:0000256|ARBA:ARBA00014997};
GN Name=YWHAQ {ECO:0000313|Ensembl:ENSMLEP00000011694.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000011694.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000011694.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Adapter protein implicated in the regulation of a large
CC spectrum of both general and specialized signaling pathways. Binds to a
CC large number of partners, usually by recognition of a phosphoserine or
CC phosphothreonine motif. Binding generally results in the modulation of
CC the activity of the binding partner. Negatively regulates the kinase
CC activity of PDPK1. {ECO:0000256|ARBA:ARBA00025150}.
CC -!- SIMILARITY: Belongs to the 14-3-3 family.
CC {ECO:0000256|ARBA:ARBA00006141, ECO:0000256|RuleBase:RU003466}.
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DR AlphaFoldDB; A0A2K5Y827; -.
DR STRING; 9568.ENSMLEP00000011694; -.
DR Ensembl; ENSMLET00000035119.1; ENSMLEP00000011694.1; ENSMLEG00000030005.1.
DR GeneTree; ENSGT01090000260040; -.
DR OMA; NPKRACE; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR CDD; cd10023; 14-3-3_theta; 1.
DR Gene3D; 1.20.190.20; 14-3-3 domain; 1.
DR InterPro; IPR000308; 14-3-3.
DR InterPro; IPR023409; 14-3-3_CS.
DR InterPro; IPR036815; 14-3-3_dom_sf.
DR InterPro; IPR023410; 14-3-3_domain.
DR InterPro; IPR042584; 14-3-3_theta.
DR PANTHER; PTHR18860; 14-3-3 PROTEIN; 1.
DR PANTHER; PTHR18860:SF3; 14-3-3 PROTEIN THETA; 1.
DR Pfam; PF00244; 14-3-3; 1.
DR PIRSF; PIRSF000868; 14-3-3; 1.
DR PRINTS; PR00305; 1433ZETA.
DR SMART; SM00101; 14_3_3; 1.
DR SUPFAM; SSF48445; 14-3-3 protein; 1.
DR PROSITE; PS00796; 1433_1; 1.
DR PROSITE; PS00797; 1433_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 6..245
FT /note="14-3-3"
FT /evidence="ECO:0000259|SMART:SM00101"
FT SITE 59
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000256|PIRSR:PIRSR000868-1"
FT SITE 130
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000256|PIRSR:PIRSR000868-1"
SQ SEQUENCE 248 AA; 28004 MW; 4279A31EEE839D6F CRC64;
APAMEKTELI QKAKLAEQAE RYDDMATCMK AVTEQGAELS NEERNLLSVA YKNVVGGRRS
AWRVISSIEQ KTDTSDKKLQ LIKDYREKVE SELRSICTTV LELLDKYLIA NATNPESKVF
YLKMKGDYFR YLAEVACGDD RKQTIDNSQG AYQEAFDISK KEMQPTHPIR LGLALNFSVF
YYEILNNPEL ACTLAKTAFD EAIAELDTLN EDSYKDSTLI MQLLRDNLTL WTSDSAGEEC
DAAEGAEN
//
