ID A0A2K5Y995_MANLE Unreviewed; 79 AA.
AC A0A2K5Y995;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Cyclin-dependent kinases regulatory subunit {ECO:0000256|RuleBase:RU311113};
GN Name=CKS1B {ECO:0000313|Ensembl:ENSMLEP00000012118.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000012118.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000012118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC kinases and is essential for their biological function.
CC {ECO:0000256|ARBA:ARBA00002449, ECO:0000256|RuleBase:RU311113}.
CC -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase
CC subunits. {ECO:0000256|ARBA:ARBA00011253}.
CC -!- SIMILARITY: Belongs to the CKS family. {ECO:0000256|ARBA:ARBA00007782,
CC ECO:0000256|RuleBase:RU311113}.
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DR RefSeq; XP_011837503.1; XM_011982113.1.
DR RefSeq; XP_011842831.1; XM_011987441.1.
DR RefSeq; XP_011842832.1; XM_011987442.1.
DR AlphaFoldDB; A0A2K5Y995; -.
DR SMR; A0A2K5Y995; -.
DR STRING; 9568.ENSMLEP00000012118; -.
DR Ensembl; ENSMLET00000035544.1; ENSMLEP00000012118.1; ENSMLEG00000030222.1.
DR GeneID; 105541193; -.
DR GeneID; 105544826; -.
DR KEGG; mleu:105541193; -.
DR CTD; 1163; -.
DR GeneTree; ENSGT00950000182971; -.
DR OMA; HYANHKP; -.
DR OrthoDB; 204504at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR Gene3D; 3.30.170.10; Cyclin-dependent kinase, regulatory subunit; 1.
DR InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR PANTHER; PTHR23415:SF50; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 1; 1.
DR PANTHER; PTHR23415; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7; 1.
DR Pfam; PF01111; CKS; 1.
DR PRINTS; PR00296; CYCLINKINASE.
DR SMART; SM01084; CKS; 1.
DR SUPFAM; SSF55637; Cell cycle regulatory proteins; 1.
DR PROSITE; PS00944; CKS_1; 1.
DR PROSITE; PS00945; CKS_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU311113};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU311113};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
SQ SEQUENCE 79 AA; 9660 MW; E64207B140FA38D5 CRC64;
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ SQGWVHYMIH
EPEPHILLFR RPLPKKPKK
//
