ID   A0A2K5YA39_MANLE        Unreviewed;       578 AA.
AC   A0A2K5YA39;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Tubulin-specific chaperone E {ECO:0000256|ARBA:ARBA00015004};
DE   AltName: Full=Tubulin-folding cofactor E {ECO:0000256|ARBA:ARBA00030180};
GN   Name=TBCE {ECO:0000313|Ensembl:ENSMLEP00000012415.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000012415.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000012415.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the TBCE family.
CC       {ECO:0000256|ARBA:ARBA00006286}.
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DR   RefSeq; XP_011844748.1; XM_011989358.1.
DR   AlphaFoldDB; A0A2K5YA39; -.
DR   STRING; 9568.ENSMLEP00000012415; -.
DR   Ensembl; ENSMLET00000035845.1; ENSMLEP00000012415.1; ENSMLEG00000030382.1.
DR   GeneID; 105546230; -.
DR   KEGG; mleu:105546230; -.
DR   CTD; 6905; -.
DR   GeneTree; ENSGT00530000063405; -.
DR   OrthoDB; 11880at2759; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005840; C:ribosome; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR   GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR   GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR   GO; GO:0014889; P:muscle atrophy; IEA:Ensembl.
DR   GO; GO:0048936; P:peripheral nervous system neuron axonogenesis; IEA:Ensembl.
DR   GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd17044; Ubl_TBCE; 1.
DR   Gene3D; 3.30.1230.20; -; 1.
DR   Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR001931; Ribosomal_eS21.
DR   InterPro; IPR038579; Ribosomal_eS21_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR044079; Ubl_TBCE.
DR   PANTHER; PTHR15454:SF7; DYNEIN AXONEMAL LIGHT CHAIN 1; 1.
DR   PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR   Pfam; PF01302; CAP_GLY; 1.
DR   Pfam; PF14580; LRR_9; 1.
DR   Pfam; PF01249; Ribosomal_S21e; 1.
DR   SMART; SM01052; CAP_GLY; 1.
DR   SUPFAM; SSF74924; Cap-Gly domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00845; CAP_GLY_1; 1.
DR   PROSITE; PS50245; CAP_GLY_2; 1.
PE   3: Inferred from homology;
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          27..71
FT                   /note="CAP-Gly"
FT                   /evidence="ECO:0000259|PROSITE:PS50245"
SQ   SEQUENCE   578 AA;  65220 MW;  231AEC66ECA3D403 CRC64;
     MSDTLTPDVI GRRVEVNGEH ATVRFAGVVP SVAGPWLGVE WDNPERGKHD GSHEGTVYFK
     CRHPTGGSFI RPNKVNFGTD FLTAIKNRYV LEDGPEEDRK EQIVTLGNKP VETVGFDSLM
     KQQSQLSKLQ EVSLRNCAVS CAGEKGGVAE ACPNIRRVDL SKNLLSSWDE VIHIADQLRH
     LEVLNLSENK LKFPSGSALT GTFSALKVLV LNQTGITWAE AHVQCGSSRH GLDMQKDASK
     FVDLCMRQKC STSNCVISAK DHISMWMNVA KVLRCAAWCP GLEELYLESN NIVISERPTD
     VLQTVKLLDL SSNQLIDENQ LYLIAQLPRL EQLILSDVGI SSIHFPDAGI GCKTSMFPSL
     QYLVVNDNQI SQWSFFNELD KLPSLRALSC LRNPLTKEDK EANTTRQLII ASIGQLKTLN
     KCEILPKERR TAELDYRKAF GNEWKQAGGH QDPDKNRLSE EFLRAHPRYQ FLCLKYGAPE
     DWELKTQQPF MLKNQLLTLK IKYPDQLDQK VLEKQLPGSM TIQKVKGWLS RLLKVPVSDL
     LLSYESPKEP GIEIKLENDL QSLRFYSVEN EDCLLVRW
//