ID A0A2K5YAC9_MANLE Unreviewed; 473 AA.
AC A0A2K5YAC9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Centrosomal protein 57 {ECO:0000313|Ensembl:ENSMLEP00000012509.1};
GN Name=CEP57 {ECO:0000313|Ensembl:ENSMLEP00000012509.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000012509.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000012509.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR RefSeq; XP_011856339.1; XM_012000949.1.
DR AlphaFoldDB; A0A2K5YAC9; -.
DR Ensembl; ENSMLET00000035940.1; ENSMLEP00000012509.1; ENSMLEG00000030398.1.
DR GeneID; 105554455; -.
DR CTD; 9702; -.
DR GeneTree; ENSGT00530000063695; -.
DR OMA; DLQRSPW; -.
DR OrthoDB; 5396442at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF11; CENTROSOMAL PROTEIN OF 57 KDA; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 68..243
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 324..393
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..237
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 53788 MW; 86CAAC88DCBF97C9 CRC64;
MAAASVSAAS GSQLSNILAE PSRSNGSMVR HSSSPYVVYP SDKPFLNSDL RRSPSKPTLA
YPESNSRAIF SALKNLQDKI RRLELERIQA EESVKTLSRE TIEYKKVLDE QIQERENSKN
EESKHNQELT SQLLAAENKC NLLEKQLEYM RNMIKHAEME RTSVLEKQVS LERERQHDLT
HVQSQLEKLD LLEQEYNKLT AMQALAEKKM QELEAKLHEE EQERKRMQAK AAELQTGLET
NRLTFEDKAT PRVPSARRIK KKKSKPPEKS TSPSHAVVAN VQLVLHLMKQ HSKALCNDRV
INSIPLAKQV SSRGGKSKKL SVTSPSNGIN EELAEVLQTL QDEFGQMSFD HQQLAKLIQE
SPTVELKDKL ECELEALVGR MEAKANQITK VRKYQAQLEK QKLEKQKKEL KATKKTLDEE
GNSSSRSGIT GTTNKKDFTK LRPGEKGRKN LQLLKDMQTI QNSLQSSSLC WDY
//
