ID   A0A2K5YE51_MANLE        Unreviewed;       426 AA.
AC   A0A2K5YE51;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Polynucleotide kinase 3'-phosphatase {ECO:0000313|Ensembl:ENSMLEP00000013795.1};
GN   Name=PNKP {ECO:0000313|Ensembl:ENSMLEP00000013795.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000013795.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000013795.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5YE51; -.
DR   Ensembl; ENSMLET00000037238.1; ENSMLEP00000013795.1; ENSMLEG00000031000.1.
DR   GeneTree; ENSGT00940000159302; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0046403; F:polynucleotide 3'-phosphatase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd22736; FHA_PNKP; 1.
DR   CDD; cd01625; HAD_PNP; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR041388; FHA_2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006549; HAD-SF_hydro_IIIA.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013954; PNK3P.
DR   InterPro; IPR006550; PNKP.
DR   InterPro; IPR006551; Polynucleotide_phosphatase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   NCBIfam; TIGR01664; DNA-3'-Pase; 1.
DR   NCBIfam; TIGR01662; HAD-SF-IIIA; 1.
DR   NCBIfam; TIGR01663; PNK-3'Pase; 1.
DR   PANTHER; PTHR12083; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE; 1.
DR   PANTHER; PTHR12083:SF9; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE; 1.
DR   Pfam; PF17913; FHA_2; 1.
DR   Pfam; PF08645; PNK3P; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          11..80
FT                   /note="PNK FHA"
FT                   /evidence="ECO:0000259|Pfam:PF17913"
FT   REGION          110..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   426 AA;  46242 MW;  1AC4E0ED98762864 CRC64;
     MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR
     TVAVKQLGVN PSTAGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEEIR TPESQPDTPP
     GTPPVSQDEK RDAEPPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR
     SGKVFPTGPS DWRILYPEIP CKLRELEAEG YKLVIFTNQM SIGRGKLPAE EFKAKVEAVV
     EKLGVPFQVL VATHAGLYRK PVTGMWDHLQ EQANEGAPIS IRDSIFVGDA AGRPANWAPG
     RKKKDFSCAD RLFALNLGLP FATPEEFFLK WPAAGFELPA FDPRTLSRSG PLCLPESRAL
     LSSSPEVVVA VGFPGAGKST FLKKHLVSAG YVHVNRSRDD GLLSCPRIRH GHVWLQEAVR
     GPDAGR
//