ID A0A2K5YEB0_MANLE Unreviewed; 428 AA.
AC A0A2K5YEB0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=REST corepressor 1 {ECO:0000313|Ensembl:ENSMLEP00000013886.1};
GN Name=RCOR1 {ECO:0000313|Ensembl:ENSMLEP00000013886.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000013886.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000013886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CoREST family.
CC {ECO:0000256|ARBA:ARBA00038011}.
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DR AlphaFoldDB; A0A2K5YEB0; -.
DR STRING; 9568.ENSMLEP00000013886; -.
DR Ensembl; ENSMLET00000037329.1; ENSMLEP00000013886.1; ENSMLEG00000031095.1.
DR GeneTree; ENSGT00940000155654; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0017053; C:transcription repressor complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Ensembl.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR049048; REST_helical.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR16089:SF11; REST COREPRESSOR 1; 1.
DR PANTHER; PTHR16089; REST COREPRESSOR COREST PROTEIN-RELATED; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR Pfam; PF20878; REST_helical; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 1..131
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 132..183
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 323..374
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 186..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 280..307
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 219..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 49132 MW; FB205191F4D51A4D CRC64;
MSKSRAAYCK ISKSRKGLAS RNVSADSVAS PISILTLRLS IVTYCLLYVL NFNEIFLFSF
SQAKLARRSQ ERDNLGMLVW SPNQNLSEAK LDEYIAIAKE KHGYNMEQAL GMLFWHKHNI
EKSLADLPNF TPFPDEWTVE DKVLFEQAFS FHGKTFHRIQ QMLPDKSIAS LVKFYYSWKK
TRTKTSVMDR HARKQKRERE ESEDELEETN GNNPIDIEVD QNKESKKEVP PTETVPQVKK
EKHSTQAKNR AKRKPPKGMF LSQEDVEAVS ANATAATTVL RQLDMELVSV KRQIQNIKQT
NSALKEKLDG GIEPYRLPEV IQKCNARWTT EEQLLAVQAI RKYGRDFQAI SDVIGNKSVV
QVKNFFVNYR RRFNIDEVLQ EWEAEHGKEE TNGPSNQKPV KSPDNSIKVP EEEDEAPSVL
DVRYASAS
//
