ID A0A2K5YGG4_MANLE Unreviewed; 1135 AA.
AC A0A2K5YGG4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Par-3 family cell polarity regulator beta {ECO:0000313|Ensembl:ENSMLEP00000014646.1};
GN Name=PARD3B {ECO:0000313|Ensembl:ENSMLEP00000014646.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000014646.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000014646.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR RefSeq; XP_011847864.1; XM_011992474.1.
DR AlphaFoldDB; A0A2K5YGG4; -.
DR Ensembl; ENSMLET00000038097.1; ENSMLEP00000014646.1; ENSMLEG00000031270.1.
DR GeneID; 105548452; -.
DR CTD; 117583; -.
DR GeneTree; ENSGT00950000183214; -.
DR OrthoDB; 5405986at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF4; PARTITIONING DEFECTIVE 3 HOMOLOG B; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 200..288
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 382..455
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 497..572
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 83..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..781
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1097
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1135 AA; 124963 MW; B0FD821652FF97F5 CRC64;
MKVTVCFGRT GIVVPCKEGQ LRVGELTQQA LQRYLKTREK GPGYWVKIHH LEYTDGGILD
PDDVLADVVE DKDKLIAVFE EQEPLHKIES PSGNPAERQS PDAFETEVAS QLAAFKPIGG
EIEVTPSALK LGTPLLVRRS SDPVPGPPAD TQPGASHPGG QSLKPVVSDF MQNLEEREVM
NGVQTELTSP KTKDTLSDMT RTVEISGEGG PLGIHVVPFF SSLSGRILGL FIRGIEENSR
SKREGLFHEN ECIVKINSVD LVDKTFAQAQ DVFRQAMKSP SVLLHVLPPQ NREQYEKSVI
GPLNIFGNND GVLKTKAPPP VHGKSGLKTA NLTGAESPET DASTCLQQNK SPRVPRLGGK
PSSPSLSPLM GFGSKKNAKK IKIDLKKGPE GLGFTVVTRD SSIHGPGPIF VKNILPKGAA
IKDGRLQSGD RILEVNGRDV TGRTQEELVA MLRSTKQGET ASLVIARQEG HFLPRELKGE
PDCCALSLET SEQLTFEIPL NDSGSAGLGV SLKGNKSRET GTDLGIFIKS IIHGGAAFKD
GRLRMNDQLI AVNGESLLGK SNHEAMETLR RSMSMEGNIR GMIQLVILRR PERPMEDPAE
CGAFSKPCFE NCQNAVTTSR RNDNSTLHPL GTYSPQDKQK DLLLPNDGWT ESEVPPSPTP
HSALELGLED YSHSSGVDSA VYFPDQHINF RSVTPARQPE SINLKASKSM DLVPDESKVH
SLAGHKSDGL SDKSSHSGQG ALNCESAPQG NSELEDMENK ARKVKKTKEK EKKKEKGKLK
VKEKKRKEEN EDPERKIKKK GFSAMLRFGK KKEDKGGKAE QKGALKHGGL REEELEKMKE
ERERIGAKHQ ELREKQARGL LDYATGAIGS VYDMDDDEMD PNYARVNHFR EPCTSANVFR
SPSPPRAGPF GYPRDGRPLS PERDHLEGLY AKVNKPYHPL APADSGRPTG GSTDRIQKLR
KEYYQARREG FPLYEDSEGR ARPSEYDLLW VPGKGPDGNA HNLRFDGLER QYASLPRGGP
TDAVDYLPAA PRGLYKEREL PYYPGAHPMH PPKGSYPRPT ELRVADLRYP QHYPPPPAPQ
HKGPFRQDVP PSPPQHQRMP AYQETGRPGP RGGSPDQYPY RTQDSRQKNP MTAAV
//
