ID A0A2K5YGM0_MANLE Unreviewed; 298 AA.
AC A0A2K5YGM0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Solute carrier family 8 member A3 {ECO:0000313|Ensembl:ENSMLEP00000014708.1};
GN Name=SLC8A3 {ECO:0000313|Ensembl:ENSMLEP00000014708.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000014708.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000014708.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_011856307.1; XM_012000917.1.
DR AlphaFoldDB; A0A2K5YGM0; -.
DR Ensembl; ENSMLET00000038159.1; ENSMLEP00000014708.1; ENSMLEG00000031498.1.
DR GeneID; 105554433; -.
DR CTD; 6547; -.
DR GeneTree; ENSGT00940000157547; -.
DR OMA; VEMANYH; -.
DR OrthoDB; 462435at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 1.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF7; SODIUM_CALCIUM EXCHANGER 3; 1.
DR Pfam; PF01699; Na_Ca_ex; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 124..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..288
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 298 AA; 32773 MW; 04A1594874EA3324 CRC64;
MERGISELTD RKLTMEEEEA KRIAEMGKPV LGEHPKLEVI IEESYEFKTT VDKLIKKTNL
ALVVGTHSWR DQFMEAITVS AAGDEDEDES GEERLPSCFD YVMHFLTVFW KVLFACVPPT
EYCHGWACFA VSILIIGMLT AIIGDLASHF GCTIGLKDSV TAVVFVAFGT SVPDTFASKA
AALQDVYADA SIGNVTGSNA VNVFLGIGLA WSVAAIYWAL QGQEFHVSAG TLAFSVTLFT
IFAFVCISVL LYRRRPHLGG ELGGPRGCKL ATTWLFVSLW LLYILFATLE AYCYIKGF
//
