ID   A0A2K5YH04_MANLE        Unreviewed;       753 AA.
AC   A0A2K5YH04;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Zw10 kinetochore protein {ECO:0000313|Ensembl:ENSMLEP00000014827.1};
GN   Name=ZW10 {ECO:0000313|Ensembl:ENSMLEP00000014827.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000014827.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000014827.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000256|ARBA:ARBA00004629}.
CC   -!- SIMILARITY: Belongs to the ZW10 family.
CC       {ECO:0000256|ARBA:ARBA00006245}.
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DR   AlphaFoldDB; A0A2K5YH04; -.
DR   STRING; 9568.ENSMLEP00000014827; -.
DR   Ensembl; ENSMLET00000038278.1; ENSMLEP00000014827.1; ENSMLEG00000031557.1.
DR   GeneTree; ENSGT00390000016427; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0070939; C:Dsl1/NZR complex; IEA:Ensembl.
DR   GO; GO:0005828; C:kinetochore microtubule; IEA:Ensembl.
DR   GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:1990423; C:RZZ complex; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:Ensembl.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR   GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR   GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:Ensembl.
DR   GO; GO:0034501; P:protein localization to kinetochore; IEA:Ensembl.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0007096; P:regulation of exit from mitosis; IEA:Ensembl.
DR   Gene3D; 1.10.357.150; -; 1.
DR   InterPro; IPR046362; Zw10/DSL1_C_sf.
DR   InterPro; IPR048343; ZW10_C.
DR   InterPro; IPR048344; Zw10_middle.
DR   InterPro; IPR009361; Zw10_N.
DR   PANTHER; PTHR12205; CENTROMERE/KINETOCHORE PROTEIN ZW10; 1.
DR   PANTHER; PTHR12205:SF0; CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG; 1.
DR   Pfam; PF20666; ZW10_C; 1.
DR   Pfam; PF20665; Zw10_middle; 2.
DR   Pfam; PF06248; Zw10_N; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Centromere {ECO:0000256|ARBA:ARBA00023328};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          27..119
FT                   /note="Centromere/kinetochore protein zw10 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06248"
FT   DOMAIN          177..247
FT                   /note="Centromere/kinetochore protein zw10 middle"
FT                   /evidence="ECO:0000259|Pfam:PF20665"
FT   DOMAIN          279..389
FT                   /note="Centromere/kinetochore protein zw10 middle"
FT                   /evidence="ECO:0000259|Pfam:PF20665"
FT   DOMAIN          446..576
FT                   /note="Centromere/kinetochore protein zw10 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20666"
FT   COILED          17..76
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   753 AA;  85851 MW;  7C200091723E6513 CRC64;
     MASFVTEVLA HSGRLEKEDL GTRISRLTRR VEEIKGEVCN MISKKYSEFL PSMQSAQGLI
     TQVDKLSEDI DLLKSRIESE VCRDLHVSTG EFTDLKQQLE RDSVVLSLLK QLQEFSTAIE
     EYNCALTEKK YVTGAQHLEE AQKCLKLLKS RKCFDLKILK SLSMELTIQK QNILYHLGEE
     WQKLIVWKFP PSKDTSSLES YLQTELHLYT EQSHKEEKTP MPPISSVLLA FSVLGELHSK
     LKSFGEACYF LLFFKPHEPN SPSFILFFCS FLTSLSLHRI EENLSLDSDL ENEKTSTVPL
     AEMLGDMIWE DLSECLIKNC LVYSIPTNSS KLQQYEEIIQ STEEFENALK EMRFLKGDTT
     DLLKYARNIN SHFANKKCQD VIVAARNLMT SEIHNTVKII PDSKINVPEL PTPDEDNKLE
     VQKVSNTQYN EVVNLEPENT LDQHSFSLPT CRISESVKKL MELAYQTLLE ATTSSDQCAV
     QLFYSVRNIF HLFHDVVPTY HKENLQKLPQ LAAIHHNNCM YIAHHLLTLG HQFRLRLAPI
     LCDGTATFVD LVPGFRRLGT ECFLAQMRAQ KGELLERLSS ARNFSNMDDE ENYSVASKAV
     RQVLHQLKRL GIVWQDVLPV NIYCKAMGTL LNTAVSEIIG KITALEDIST EDGDRLYSLC
     KTVMDEGPQV FAPLSEESKN KKYQEEVPVY VPKWMPFKEL MMMLQASLQE IGDRWADGKG
     PLAAAFSSSE VKALIRALFQ NTERRAAALA KIK
//