ID   A0A2K5YHJ3_MANLE        Unreviewed;       882 AA.
AC   A0A2K5YHJ3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=MutS homolog 4 {ECO:0000313|Ensembl:ENSMLEP00000015044.1};
GN   Name=MSH4 {ECO:0000313|Ensembl:ENSMLEP00000015044.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000015044.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000015044.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5YHJ3; -.
DR   STRING; 9568.ENSMLEP00000015044; -.
DR   Ensembl; ENSMLET00000038499.1; ENSMLEP00000015044.1; ENSMLEG00000031689.1.
DR   GeneTree; ENSGT00550000074897; -.
DR   OMA; KMTMLYK; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005713; C:recombination nodule; IEA:Ensembl.
DR   GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0007292; P:female gamete generation; IEA:Ensembl.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:Ensembl.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   CDD; cd03243; ABC_MutS_homologs; 1.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          700..716
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   882 AA;  98711 MW;  7A73DEB65EADFFD5 CRC64;
     MLRPEISSAS PSAPAVSPSS GETRSPQGPR YNFRLQETPQ SHPSGQVASA STPPGTSGAA
     GDRSSSSSLP CPAPGSRPAQ GSYFGNKRAY AENTVASNFT FGASSSSARD TNYPQTLKTP
     LSTGNPQRSS YKSWTPQMGY SASSSSAISA HCPSVIVAVV EGRGLARGEI GMASIDLKNP
     QIILSQFADN TTYAKNVNFT TIQRKYFNET KGLEYIEQLC IAEFSTVLME VQSFIQNSVY
     APKSLKICFQ GSEQTAMIDS SSAQNLELLI NNQDCRNNHT LFGVLNYTKT PGGSRRLRSN
     ILEPLVDVET INMRLDCVQE LLQDEELFFG LQSVISRFLD TEQLLSVLVQ IPKQDTVNAA
     ESKITNLIYL KHTLELVDPL KIAMKNCNTP LLRAYYGSLE DKRFGIILEK IKTVINDDAR
     YMKGCLNMRT QKCYAVRSNI NEFLDIARRT YTEIVDDIAG MISQLGEKYS LPLRTSFSSA
     RGFFIQMTTD CLALPNDQLP SEFIKISKVK NSYSFTSADL IKMNERCQES LREIYHMTYM
     IVCKLLSEIY EHIHCLYKLS DTVSMLDMLL SFAHACTLSD YVRPEFTDTL AIKQGWHPIL
     EKISAEKPIA NNTYITEGSN FLIITGPNMS GKSTYLKQIA LCQIMAQIGS YVPAEYSSFR
     IAKQIFTRLS TDDDIETNSS TFMKEMKEIA YILHNANDKS LILIDELGRG TNTEEGIGIC
     YAVCEYLLSL KAFTLFATHF LELCHLDALY LNVENMHFEV QHVKNTSRNK EAILYTYKLS
     KGLTEEKNYG LKAAEVSSLP PSIVLDAKEI TTQITRQILQ NQRSTPEMER QRAVYHLATR
     LVQTARNSQL DPDSLRIYLS NLKKKYKEDF PKTEQVPGKT EE
//