ID A0A2K5YHJ3_MANLE Unreviewed; 882 AA.
AC A0A2K5YHJ3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=MutS homolog 4 {ECO:0000313|Ensembl:ENSMLEP00000015044.1};
GN Name=MSH4 {ECO:0000313|Ensembl:ENSMLEP00000015044.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000015044.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000015044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5YHJ3; -.
DR STRING; 9568.ENSMLEP00000015044; -.
DR Ensembl; ENSMLET00000038499.1; ENSMLEP00000015044.1; ENSMLEG00000031689.1.
DR GeneTree; ENSGT00550000074897; -.
DR OMA; KMTMLYK; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005713; C:recombination nodule; IEA:Ensembl.
DR GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0007292; P:female gamete generation; IEA:Ensembl.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:Ensembl.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd03243; ABC_MutS_homologs; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 700..716
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 882 AA; 98711 MW; 7A73DEB65EADFFD5 CRC64;
MLRPEISSAS PSAPAVSPSS GETRSPQGPR YNFRLQETPQ SHPSGQVASA STPPGTSGAA
GDRSSSSSLP CPAPGSRPAQ GSYFGNKRAY AENTVASNFT FGASSSSARD TNYPQTLKTP
LSTGNPQRSS YKSWTPQMGY SASSSSAISA HCPSVIVAVV EGRGLARGEI GMASIDLKNP
QIILSQFADN TTYAKNVNFT TIQRKYFNET KGLEYIEQLC IAEFSTVLME VQSFIQNSVY
APKSLKICFQ GSEQTAMIDS SSAQNLELLI NNQDCRNNHT LFGVLNYTKT PGGSRRLRSN
ILEPLVDVET INMRLDCVQE LLQDEELFFG LQSVISRFLD TEQLLSVLVQ IPKQDTVNAA
ESKITNLIYL KHTLELVDPL KIAMKNCNTP LLRAYYGSLE DKRFGIILEK IKTVINDDAR
YMKGCLNMRT QKCYAVRSNI NEFLDIARRT YTEIVDDIAG MISQLGEKYS LPLRTSFSSA
RGFFIQMTTD CLALPNDQLP SEFIKISKVK NSYSFTSADL IKMNERCQES LREIYHMTYM
IVCKLLSEIY EHIHCLYKLS DTVSMLDMLL SFAHACTLSD YVRPEFTDTL AIKQGWHPIL
EKISAEKPIA NNTYITEGSN FLIITGPNMS GKSTYLKQIA LCQIMAQIGS YVPAEYSSFR
IAKQIFTRLS TDDDIETNSS TFMKEMKEIA YILHNANDKS LILIDELGRG TNTEEGIGIC
YAVCEYLLSL KAFTLFATHF LELCHLDALY LNVENMHFEV QHVKNTSRNK EAILYTYKLS
KGLTEEKNYG LKAAEVSSLP PSIVLDAKEI TTQITRQILQ NQRSTPEMER QRAVYHLATR
LVQTARNSQL DPDSLRIYLS NLKKKYKEDF PKTEQVPGKT EE
//