ID A0A2K5YK64_MANLE Unreviewed; 443 AA.
AC A0A2K5YK64;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Butyrophilin subfamily 2 member A2 {ECO:0008006|Google:ProtNLM};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000015952.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000015952.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000256|ARBA:ARBA00007591}.
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DR AlphaFoldDB; A0A2K5YK64; -.
DR STRING; 9568.ENSMLEP00000015952; -.
DR Ensembl; ENSMLET00000039418.1; ENSMLEP00000015952.1; ENSMLEG00000032175.1.
DR GeneTree; ENSGT00940000163835; -.
DR OMA; ESEYWAL; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd05713; IgV_MOG_like; 1.
DR CDD; cd15819; SPRY_PRY_BTN1_2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR037958; SPRY/PRY_BTN1/2.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24100; BUTYROPHILIN; 1.
DR PANTHER; PTHR24100:SF79; BUTYROPHILIN SUBFAMILY 2 MEMBER A1; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..443
FT /note="Butyrophilin subfamily 2 member A2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014416922"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..126
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 226..422
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 201..233
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 443 AA; 50535 MW; 02F43A91A1E1C1B1 CRC64;
MEPAAALHFS LPASLLLLLL LRLCALVSAQ FIVVGPTDSI LATVGEDTTL RCHLSPEKNA
EDMEVRWFRS QFFPAVFVYK GGRERTEEQM EEYRGRTTFV SKDISRGSVA LVIHNITAQE
NGTYRCYFQE GRSYDEAILH LVVAKKESVI FIPESFMPSV SPCVVALPII VVFLMIIIAV
CIYWINRLRK EKKILSGEKE FELETREIAV KELEKERVQR EKELQVQEQL QEELRWRRTV
LHAVDVVLDP DTAHPDLLLS EDRRSVRRCP LRHLGESVPD NPERFDSEPC VLGRESFASG
KHYWEVEVEN VIEWTVGVCR DSVQRKGEVL LIPQNGFWTL EMFGNQYRAL SSPDRILPLK
ESLCRVGVFL DYEAGDVSFY NMRDRSHIYT CPRSAFSVPV RPFFRIGSDD SPIFICPALI
GASGVTVPEE GLTLHRVGTN QSL
//
