ID A0A2K5YMZ2_MANLE Unreviewed; 860 AA.
AC A0A2K5YMZ2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=MCF.2 cell line derived transforming sequence {ECO:0000313|Ensembl:ENSMLEP00000016921.1};
GN Name=MCF2 {ECO:0000313|Ensembl:ENSMLEP00000016921.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000016921.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000016921.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011857015.1; XM_012001625.1.
DR AlphaFoldDB; A0A2K5YMZ2; -.
DR Ensembl; ENSMLET00000040392.1; ENSMLEP00000016921.1; ENSMLEG00000032441.1.
DR GeneID; 105554957; -.
DR CTD; 4168; -.
DR GeneTree; ENSGT00940000156974; -.
DR OrthoDB; 4244290at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 13..88
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 495..675
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 687..809
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 244..274
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 860 AA; 100421 MW; A2DC0A19ED40191D CRC64;
MAEANPPRGK MRFRRNAASF PGNLHLVLVL RPTSFLQRTF TDIGFRFSQE DFMLKLPVVM
LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEN FALTVKEMAQ MLQSFGTELA
ETELPDDIPS IEEILAIRAE RYHLLKNDIT AVTKEGKILL TNLEVPDTEG AVSSRLECHQ
QISGDWQTIN KLLTQVHDME TAFDGFWEKH QLKMEQYLQL WKFEQDFQQL VTEVEFLLNQ
QAELADVTGT IVQVKQKIKK LENLDENSQE LLSKAQFVIL HGHKLAANHH YALDLICQRC
NELRYLSDIL VNEIKAKRIQ LSRTFKMHKL LQQARQCCDE GECLLANQEI DKFQSKEDAQ
KALQDIENFL EMALPFINYE PETLQYEFDV ILSPELKVQM KTIQLKLENI RSIFENQQAG
FRNLVHKHVR PIQFVVPTPE NLVTSRTPFF SSKQGKKTWR QNQSNLKIEV VHDCQEKRSS
GQSSSLDNGN SLDVLKNHVL NELIQTERVY VRELYTVLLG YRAEMDNPEM FDLMPPLLRN
KKDVLFGNMA EIYEFHNDIF LSSLENCAYA PESVGPCFLE RKDDFQMYAK YCQNKPRSET
IWRKYSECAF FQECQRKLKH RLRLDSYLLK PVQRITKYQL LLKELLKYSK DCEGSALLKE
ALDAMLDLLK SVNDSMHQIA INGYIGNLNE LGKMIMQGGF SVWIGHKKGA TKMKDLARFK
PMQRHLFLYE KAIVFCKRRV ESGEGSDRYP SYSFKHCWKM DEVGFTEYVK GDNRKFEIWY
GEKEEVYIVQ APNVDVKMTW LKEIRNILLK QQELLTVKKR KQQDQLTEQD KIQISLQQND
EDPCRKWLSY IDEATMSNGK
//