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Database: UniProt
Entry: A0A2K5YMZ2_MANLE
LinkDB: A0A2K5YMZ2_MANLE
Original site: A0A2K5YMZ2_MANLE 
ID   A0A2K5YMZ2_MANLE        Unreviewed;       860 AA.
AC   A0A2K5YMZ2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=MCF.2 cell line derived transforming sequence {ECO:0000313|Ensembl:ENSMLEP00000016921.1};
GN   Name=MCF2 {ECO:0000313|Ensembl:ENSMLEP00000016921.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000016921.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000016921.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_011857015.1; XM_012001625.1.
DR   AlphaFoldDB; A0A2K5YMZ2; -.
DR   Ensembl; ENSMLET00000040392.1; ENSMLEP00000016921.1; ENSMLEG00000032441.1.
DR   GeneID; 105554957; -.
DR   CTD; 4168; -.
DR   GeneTree; ENSGT00940000156974; -.
DR   OrthoDB; 4244290at2759; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00150; SPEC; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          13..88
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          495..675
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          687..809
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   COILED          244..274
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   860 AA;  100421 MW;  A2DC0A19ED40191D CRC64;
     MAEANPPRGK MRFRRNAASF PGNLHLVLVL RPTSFLQRTF TDIGFRFSQE DFMLKLPVVM
     LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEN FALTVKEMAQ MLQSFGTELA
     ETELPDDIPS IEEILAIRAE RYHLLKNDIT AVTKEGKILL TNLEVPDTEG AVSSRLECHQ
     QISGDWQTIN KLLTQVHDME TAFDGFWEKH QLKMEQYLQL WKFEQDFQQL VTEVEFLLNQ
     QAELADVTGT IVQVKQKIKK LENLDENSQE LLSKAQFVIL HGHKLAANHH YALDLICQRC
     NELRYLSDIL VNEIKAKRIQ LSRTFKMHKL LQQARQCCDE GECLLANQEI DKFQSKEDAQ
     KALQDIENFL EMALPFINYE PETLQYEFDV ILSPELKVQM KTIQLKLENI RSIFENQQAG
     FRNLVHKHVR PIQFVVPTPE NLVTSRTPFF SSKQGKKTWR QNQSNLKIEV VHDCQEKRSS
     GQSSSLDNGN SLDVLKNHVL NELIQTERVY VRELYTVLLG YRAEMDNPEM FDLMPPLLRN
     KKDVLFGNMA EIYEFHNDIF LSSLENCAYA PESVGPCFLE RKDDFQMYAK YCQNKPRSET
     IWRKYSECAF FQECQRKLKH RLRLDSYLLK PVQRITKYQL LLKELLKYSK DCEGSALLKE
     ALDAMLDLLK SVNDSMHQIA INGYIGNLNE LGKMIMQGGF SVWIGHKKGA TKMKDLARFK
     PMQRHLFLYE KAIVFCKRRV ESGEGSDRYP SYSFKHCWKM DEVGFTEYVK GDNRKFEIWY
     GEKEEVYIVQ APNVDVKMTW LKEIRNILLK QQELLTVKKR KQQDQLTEQD KIQISLQQND
     EDPCRKWLSY IDEATMSNGK
//
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