ID   A0A2K5YNC3_MANLE        Unreviewed;       699 AA.
AC   A0A2K5YNC3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Hook microtubule tethering protein 3 {ECO:0000313|Ensembl:ENSMLEP00000017060.1};
GN   Name=HOOK3 {ECO:0000313|Ensembl:ENSMLEP00000017060.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000017060.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000017060.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the hook family.
CC       {ECO:0000256|ARBA:ARBA00006946}.
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DR   AlphaFoldDB; A0A2K5YNC3; -.
DR   Ensembl; ENSMLET00000040534.1; ENSMLEP00000017060.1; ENSMLEG00000032643.1.
DR   GeneTree; ENSGT00940000158075; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR008636; Hook_C.
DR   InterPro; IPR043936; HOOK_N.
DR   PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR   PANTHER; PTHR18947:SF38; PROTEIN HOOK HOMOLOG 3; 1.
DR   Pfam; PF05622; HOOK; 1.
DR   Pfam; PF19047; HOOK_N; 1.
DR   SUPFAM; SSF116907; Hook domain; 1.
DR   PROSITE; PS50021; CH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          1..107
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REGION          663..699
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          152..411
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          470..631
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        667..691
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   699 AA;  80909 MW;  6D9B5CAA8F83C717 CRC64;
     DSECQTSIQT FNVDAPWQTV EDLTNGVVMA QVLQKIDPAY FDENWLNRIK TEVGDNWRLK
     FLVKQTNLDQ ILGQQINDFT LPDVNLIGEH SDAAELGRML QLILGCAVNC EQKQEYIQAI
     MMMEESVQHV VMTAIQELMS KESPVSAGND AYVDLDRQLK KTTEELNEAL SAKEEIAQRC
     HELDMQVAAL QEEKSSLLAE NQVLMERLNQ SDSIEDPNSP AGRRHLQLQT QLEQLQEETF
     RLEAAKDDYR IRCEELEKEI SELRQQNDEL TTLADEAQSL KDEIDVLRHS SDKVSKLEGQ
     VESYKKKLED LGDLRRQVKL LEEKNTVYMQ NTVSLEEELR KANAARSQLE TYKRQVVELQ
     NRLSEESKKA DKLDFEYKRL KEKVDSLQKE KDRLRTERDS LKETIEELRC VQAQEGQLTT
     QGLMPLGSQE SSDSLAAEIV TPEIREKLIR LQHENKMLKL NQEGSDNEKI ALLQSLLDDA
     NLRKNELETE NRLVNQRLLE VQSQVEELQK SLQDQGSKAE DSVLLKKKLE EHLEKLHEAN
     NELQKKRAII EDLEPRFNNS SLKIEELQEA LRKKEEEMKQ MEERYKKYLE KAKSVIRTLD
     PKQNQGAAPE IQALKNQLQE RDRLFHSLEK EYEKTKSQRE MEEKYIVSAW YNMGMTLHKK
     AAEDRLASTG SGQSFLARQR QATSSRRSYP GHVQPATAR
//