ID A0A2K5YPA8_MANLE Unreviewed; 741 AA.
AC A0A2K5YPA8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Patched domain containing 3 (gene/pseudogene) {ECO:0000313|Ensembl:ENSMLEP00000017392.1};
GN Name=PTCHD3 {ECO:0000313|Ensembl:ENSMLEP00000017392.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000017392.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000017392.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5YPA8; -.
DR STRING; 9568.ENSMLEP00000017392; -.
DR Ensembl; ENSMLET00000040868.1; ENSMLEP00000017392.1; ENSMLEG00000032893.1.
DR GeneTree; ENSGT00940000158727; -.
DR OMA; ERMGECM; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796:SF60; PATCHED DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 268..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 356..513
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 741 AA; 84050 MW; FEA0CFCE4FA4A1B6 CRC64;
MPWVEPEPRP SPEQKPKLTK QYSATGPEWD QKSEESESEG NQPPLGPLAS PRPPETPGPP
ALERDDAPLP EEETPEPRAI CRHRHRCHTD CLEAPLSRAF QWLGWQVGAH PWIFLLASLM
LTAALSTGFL YLPKGKEEDL EEQYTPVGGP AKAERRFVQG HFTTDDSYRF SASRRSTEAN
FASLLVVSYS DSLLDPATFA EVSKLDGAVQ DLRVALEDGS QIQYQQVCAR NRTLCVHPNP
LLHAWQVDKT LNLSSISFPI YHHGGHPLYL TGFFGGRILG GSLGMGHLLL RAKAMRLLYY
LKTEDPEDRV QSKQWLTHFL DQFTNITNTL ALKKIEVVHF TSLSRQLEFQ ATSKTMIPVF
HLAHVPIILF AVASCFRFDR IRNKMCVAAF GVISAFLAVV SGFGLLLHIG VPCVIIVANS
PFLILSVGVD NMFIMISTWH KTRLADDIPE RMSNVYSKVA VSITITTITN ILAFYTGVMS
SFRSVQCFCI YTGTTLLFCY FYSITCFGAF MALDGKREVV CLRWLQKADP KWSSFKKSCC
CPCGSVPDEH GTYVHPMNLF FRDYFGPFLT SSKSKYFVVF VYILYIISSI YGCFHVQKGL
DFRNLASDDS YITPYFNVEE DYFSDYGPRV MVIVTKKVDY WNEDVRQKLE NCIKIFENKV
YVDKNLTEFW LDAYVQYLKS NSQDPNDKNT FMNNIPDFLS NFPNFQHDIN ISSSNEIISS
RGFIQTTGVS SSTKKKIMLF Q
//
