ID A0A2K5YPH5_MANLE Unreviewed; 2639 AA.
AC A0A2K5YPH5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=MAX dimerization protein MGA {ECO:0000313|Ensembl:ENSMLEP00000017456.1};
GN Name=MGA {ECO:0000313|Ensembl:ENSMLEP00000017456.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000017456.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000017456.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR Ensembl; ENSMLET00000040932.1; ENSMLEP00000017456.1; ENSMLEG00000032892.1.
DR GeneTree; ENSGT00940000156269; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0071339; C:MLL1 complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18911; bHLHzip_MGA; 1.
DR CDD; cd20195; T-box_MGA-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR037935; MAX_gene-associated_bHLHzip.
DR InterPro; IPR032060; MGA_dom.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF32; MAX GENE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF16059; MGA_dom; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 79..260
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT DOMAIN 1997..2048
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 259..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1539..1633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1716..1739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1949..1970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2104..2125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2149..2170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2244..2282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2520..2555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2599..2618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 892..923
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1544..1570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1873..1887
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2151..2170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2249..2279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2529..2555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2639 AA; 291149 MW; 400A32AA82BB8990 CRC64;
MEEKQQIILA NQDGGTVAGA APTFFVILKQ PGNGKTDQGI LVTNQDACAL ASSVSSPVKS
KGKICLPADC TVGGITVTLD NNSMWNEFYH RSTEMILTKQ GRRMFPYCRY WITGLDSNLK
YILVMDISPV DNHRYKWNGR WWEPSGKAEP HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK
LTNNTLDQEG HIILHSMHRY LPRLHLVPAE KAVEVIQLNG PGVHTFTFPQ TEFFAVTAYQ
NIQITQLKID YNPFAKGFRD DGLNSKPQRD GKQKNNSDQE GNIISSSSGH RVRLTEGQGS
EIQPGDLDPL SRGHETSGKG LEKTSLNIKR DFLGFMDTDS ALSEVPQLKQ EISECLIASS
FADDSHVASP LDQNGSFNVV IKEEPLDDYD YELGECPEGV TVKQEETDEE TDVYSNSDDD
PILEKQLKRH NKVDNPEADH LSSKWLPSSP SGVAKAKMFK LDTGKMPVVY LEPCAVTRST
VKISELPDNM LSTSRKDKSS MLAELEYLPT YIENSNETAF CLGKESENGL RKHSSDLRVV
QKYPSLKDSQ WKYPDISDSI NTERILDSSK GSVGDLLSGK EDLGRKRTTM LKIATPPKVV
NANQNASPNV PGKRGRPRKL KLCKAGRPPK NTGKSLISTK NTPVGPGSTF PDVKPDLEDV
DGVLFVSFES KEALDIHAVD GTTEESSSLQ ASTTNDSGYR ARISQLEKEL IEDLKSLRHK
QVIHPGLQEV GLKLNSVDPT VSIDLKYLGV QLPLAPATSF PFWNLSGTNP ASPDAGFPFV
SRTGKTNDFT KIKGWRGKFH SASASRNEAS LKTKPIHTII RKRAPPCNND FCRLGCVCSS
LALEKRQPAH CRRPDCMFGC TCLKRKVVLV KGGSKTKHFQ RKAAHPRDPV FYDTLGEEAR
EEEEGIREEE EQLKEKKKRK KLEYTICETE PEQPVRHYPL WVKVEGEVDP EPVYIPTPSV
IEPMKPLLLP QPEVLSPTVK GKLLTGIKSA RSYIPRPNPV IREEDKDPVY LYFESMMTCA
RVRVYERKKE DQRQPSSSSS PSPSFQQQSL CHSSPENHSN AKEPDCEQQP LKQLTCDLED
DSDKLQEKSW KSPCNEGESS STSYMHQRSP GGPTKLIEII SDCNWEEDRN KILSILSQHI
NSNMPQSLKV GSFIIELASQ RKSRGEKNPP VYSSRVKISM PSCQDQDDMA EKSGSETPDG
PLSPGKMEDI SPVQTDALDS VRERLHGGKG LPFYAGLSPA GKLVAYKRKP SSSTSGLIQV
ASNAKVAASR KPRTLLPSTS NSKMASSSGT ATNRPGKNLK AFVPAKRPIE NAAQIPVATP
QVSPNTVKRA GPRLLLIPVQ QGSPTLRPVS NTQLQGHRMV LQPVRSPSGM NLFRHPNGQI
VQLLPLHQLR GSNTQPNLQP VMFRNPGSVM GIRLPAPSKP SETPPSSTSS SAFSVMNPVI
QAVGSSSAVN VITQAPSLLS SGASFVSQAG TLTLRISPPE PQSFASKTGS ETKITYSSGG
QPVGTASLIP LQSGSFALLQ LPGQKPVPSS ILQHVASLQM KRESQNPDQK DETNSIKREQ
ETKKVLQSEG EAVDSEANII KQNSGAATSE ETLNDSLEDR GDHLDEESLP EEGSATVKPS
EHSCITGSHT DQDYKDVNEE YGARNRNSSK EKVAVLEVRT ISEKAGNKTV QNLSKVQHQK
LGDVKVEQQK VLDNPEENSS EFPVTFKEES KFELSGSKVM EQQSNPQPEA KEKECGDSLE
KDSIRERWRK HLKGPLTRKC VGASQECKKE VDEQLIKETK TCQENSDVFQ QEQGISDLLG
KSGITEDARV LKTECDSWSR ISNPSAFSIV PRRAAKSSRG NGHFQGHLLL PGEQIQPKQE
KKGGRSSADF TVLDLEEDDD DENEKTDDSI DEIVDVVSDY QSEEVDDVEK TNCVEYIEDD
EEHVDIETVE ELSEEINVAH LKTTVAHTQS FKQPSRTHIS ADEKAAERSR KAPPIPLKLK
PDYWSDKLQK EAEAFAYYRR THTANERRRR GEMRDLFEKL KITLGLLHSS KVSKSLILTR
AFSEIQGLTD QADKLIGQKN LLTRKRNILI RKVSSLSGKT EEVVLKKLEY IYAKQQALEA
QKRKKKMGSD EFDMSPRISK QQEGSSTSCV DLGQMFINNR RGKPLILSRK KDQATENTSP
SNTPHTSANL VMTPQGQLLT LKGPLFSGPV VTVSPDLLES DLKPQVASSA VALPENDDLF
MMPRIVNVTS LATEGGLVDM GGSKYPHEVP DGKPSDHLKD TVRNEDNSLE DKSRISSRGN
RDGRVMLGPT QVFLANKDSG YPQIVDVSSM QKAQEFLPKK ISGDMRGIQY KWKESESRGE
RVKSKESSFH KLKMKDLKDS SIEMELRKVT SAIEEAALDS SELLTNMEDE DDTDETLTSL
LNEIAFLNQQ LNDDSVSLAE LPSSMDTEFP GDARRAFISK VTSGNRAAFQ VEHLGTGLKE
LPDVQGESDS ISPLLLHLED DDFSENEKQL AEPASEPDVL KIVIDSEIKD SLLSNKKAID
GGKNTSGLLA EPESVSSPPT LHMKTGLENS NSTDTLWRPM PKLAPLGLKV ANPSSDADGQ
SLKVMPCLAP IAAKVGSVGH KMNLTGNDPE GRESKVMPTL APVVAKLGNS GASPSSAGK
//
