ID A0A2K5YQZ3_MANLE Unreviewed; 1229 AA.
AC A0A2K5YQZ3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=SAM and SH3 domain containing 1 {ECO:0000313|Ensembl:ENSMLEP00000017939.1};
GN Name=SASH1 {ECO:0000313|Ensembl:ENSMLEP00000017939.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000017939.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000017939.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5YQZ3; -.
DR STRING; 9568.ENSMLEP00000017939; -.
DR Ensembl; ENSMLET00000041419.1; ENSMLEP00000017939.1; ENSMLEG00000033121.1.
DR GeneTree; ENSGT00940000156778; -.
DR OMA; SMSDWLI; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:Ensembl.
DR GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:1902498; P:regulation of protein autoubiquitination; IEA:Ensembl.
DR GO; GO:1900044; P:regulation of protein K63-linked ubiquitination; IEA:Ensembl.
DR CDD; cd09559; SAM_SASH1_repeat1; 1.
DR CDD; cd09492; SAM_SASH1_repeat2; 1.
DR CDD; cd11967; SH3_SASH1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037627; SASH1_SAM_repeat1.
DR InterPro; IPR037630; SASH1_SAM_repeat2.
DR InterPro; IPR035720; SASH1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR021090; SPIDER.
DR PANTHER; PTHR12301:SF3; SAM AND SH3 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12301; SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF12485; SLY; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 531..592
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 610..674
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1159..1223
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 103..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1042
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1229 AA; 135072 MW; B84B4F2ABE5CE1FA CRC64;
APEPEPEPEP GAGTSEAFSQ LWTDVMGILD GSLGNIDDLA QQYADYYNTC FSDVCERMEE
LRKRRVSQDL DVEKPDASPT SLQLRSQIEE SLGFCSAVST PEVERKNPLH KSNSEDNSVG
KGDWKKKNKY FWQNFRKNQK GIMRQTSKGE DVGYVASEIT MSDEERIQLM MMVKEKMITI
EEALARLKEY EAQHRQSAAL DPADWPDGSY PTFDGSSNCN SREQSDDETE ESVKFKRLHK
LVNSTRRVRK KLIRVEEMKK PSTEGGEEHV FENSPVLDER SALYSGVHKK PFFFDGSPEK
PPEDDSDSLT TSPSSSSLDT WGAGRKLVKT FSKGESRGLI KPPKKMGTFF SYPEEEKAQK
VSRSLTEGEM KKSLGSLSHG RTCSFGGFDL TNRSLHVGTN NSDPMGKEGD FVYKEVIKSP
TASRISLGKK VKSVKETMRK RMSKKYSSSV SEQDSGLDGM PGSPPPSQPD PEHLDKPKLK
AGGSVESLRS SLSGQSSMSG QTVSTTDSSA SNRESVKSED GDDEEPPYRG PFCGRARVHT
DFTPSPYDTD SLKLKKGDII DIISKPPMGT WMGLLNNKVG TFKFIYVDVL SEDEEKPKRP
TRRRRKGRPP QPKSVEDLLD RINLKEHMPT FLFNGYEDLD TFKLLEEEDL DELNIRDPEH
RAVLLTAVEL LQEYDSNSDQ SGSQEKLLVD SQGLSGCSPR DSGCYESSEN LENGKTRKAS
LLSAKSSAEP NLKSFSRNQL GNYPTLPLTK SGDALKQGQE EGRLGGGLAP DTSKSCDPPS
VTGLNKNRRS LPVSICRSCE TLEGPQTVDT WPRSHSLDDL QAEPGAEQDV PTEVTEPPPQ
IVPKVPQKMT ASSTKAQPLE RDSAVDNALL LTQSKRFSEP QKLTTKKLEG SIAASGRSLS
PPQCLPRNYD AQAPGAKHGL ARTPLEGHRI GHEFEGTHHP LGTKEGVDAE QRVPEARTQP
KIPSQPPPVP AKKSRERLAN GLYPVPMGPG GTLPSPDAPC LPVKRGSPTS PTSPSDCPPA
LAPRPLSGQA PGSPPSTRPP PWLSELPENT SLQEHGVKLG PALTRKVSCA RGVDLEMLTE
NKLHAEGIDL TEEPYSDKHG RCGIPEALVQ RYAEDLDQPE RDVAINMDQI RVKQLRKQHR
MAIPSGGLTE ICRKPVSPGC ISSVSDWLIS IGLPMYASTL STAGFSTLSQ VPSLSHTCLQ
EAGITEERHI RKLLSAARLF KLPPGPEAM
//