ID A0A2K5YRL7_MANLE Unreviewed; 476 AA.
AC A0A2K5YRL7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=G-patch domain and KOW motifs-containing protein {ECO:0000256|RuleBase:RU369096};
GN Name=GPKOW {ECO:0000313|Ensembl:ENSMLEP00000018203.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000018203.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000018203.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: RNA-binding protein involved in pre-mRNA splicing.
CC {ECO:0000256|RuleBase:RU369096}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369096}.
CC -!- SIMILARITY: Belongs to the MOS2 family. {ECO:0000256|ARBA:ARBA00010966,
CC ECO:0000256|RuleBase:RU369096}.
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DR RefSeq; XP_011846762.1; XM_011991372.1.
DR AlphaFoldDB; A0A2K5YRL7; -.
DR STRING; 9568.ENSMLEP00000018203; -.
DR Ensembl; ENSMLET00000041685.1; ENSMLEP00000018203.1; ENSMLEG00000033293.1.
DR GeneID; 105547703; -.
DR KEGG; mleu:105547703; -.
DR CTD; 27238; -.
DR GeneTree; ENSGT00390000015154; -.
DR OMA; AHKDKEK; -.
DR OrthoDB; 55448at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005681; C:spliceosomal complex; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:Ensembl.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd13152; KOW_GPKOW_A; 1.
DR CDD; cd13153; KOW_GPKOW_B; 1.
DR Gene3D; 2.30.30.30; -; 2.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR041993; GPKOW_KOW1.
DR InterPro; IPR041994; GPKOW_KOW2.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR045166; Spp2-like.
DR InterPro; IPR026822; Spp2/MOS2_G-patch.
DR PANTHER; PTHR15818; G PATCH AND KOW-CONTAINING; 1.
DR PANTHER; PTHR15818:SF2; G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN; 1.
DR Pfam; PF12656; G-patch_2; 1.
DR Pfam; PF00467; KOW; 2.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00739; KOW; 2.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU369096};
KW mRNA splicing {ECO:0000256|RuleBase:RU369096};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369096};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 164..210
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 52287 MW; 91EE9AEDD6CEAC89 CRC64;
MADSEEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAR PSPEEKDFLK TVEGRELQSV
KPQESPKELV IPLIQNGHRR QSPARPPGPS TDTEALADGV LSQAVKELIE ESKKSLEERE
NAGVDPTLAI PMIQKGCTPS GEGADSEPRA ETVPEEANYE AVPVEAYGLA MLRGMGWKPG
EGIGRTFNQV VKPRVNSLRP KGLGLGANLT EAQALTSTGP SHMPRPDEEQ EKNKEDQPQG
LVPGGAVVVL SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYCLR PVSQQEFNKN
TLDLRQQNGT ASSRKTLRNQ ELHVQQDNSE RKRKHLPDRL DGPAAKSEKA APRSQHWLHR
DLRVRFVDKM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR VLEGLREDML ETLVPKAEGD
RVMVVLGPQA GRVGHLLSRD RARSRALVQL PRENQVVELH YDAICQYMGP SDTDDD
//
