ID A0A2K5YT84_MANLE Unreviewed; 1725 AA.
AC A0A2K5YT84;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Trinucleotide repeat containing adaptor 6C {ECO:0000313|Ensembl:ENSMLEP00000018782.1};
GN Name=TNRC6C {ECO:0000313|Ensembl:ENSMLEP00000018782.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000018782.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000018782.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GW182 family.
CC {ECO:0000256|ARBA:ARBA00007302}.
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DR RefSeq; XP_011843485.1; XM_011988095.1.
DR Ensembl; ENSMLET00000042269.1; ENSMLEP00000018782.1; ENSMLEG00000033436.1.
DR GeneID; 105545224; -.
DR KEGG; mleu:105545224; -.
DR CTD; 57690; -.
DR GeneTree; ENSGT00940000157598; -.
DR OrthoDB; 5407035at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd12713; RRM_TNRC6C; 1.
DR CDD; cd14283; UBA_TNR6C; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR019486; Argonaute_hook_dom.
DR InterPro; IPR026805; GW182_M_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR041917; TNR6C_UBA.
DR InterPro; IPR032226; TNRC6_PABC-bd.
DR InterPro; IPR034927; TNRC6C_RRM.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR PANTHER; PTHR13020:SF9; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN; 1.
DR Pfam; PF10427; Ago_hook; 1.
DR Pfam; PF12938; M_domain; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF16608; TNRC6-PABC_bdg; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 929..974
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1475..1521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1637..1658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1177..1208
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 228..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1222
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1408..1447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1637..1654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1725 AA; 179340 MW; B37A03BDA8717A9F CRC64;
MATGSAQGNF TGHTKKTNGN NGTNGALVQS PSNQSALGAG GANSNGSATR VWGVATGSSS
GLAHCSISGG DGKMDTMIGD GRSQNCWGAS NSNAGINLNL NPNANPAAWP VLGHEGTVAT
GNPSSICSPV SAIGQNMGNQ NGNPTGTLGA WGNLLPQEST EPQTSTSQNV SFSAQPQNLN
TDGPNNTNPM NSSPNPINAM QTNGLPNWGM AVGMGAIIPP HLQSLPGANG SSVSQVSGGS
AEGISNSVWG LSPGNPATGN SNSGFSQGNG DTVNSALSAK QNGSSSAVQK EGNGGNAWDS
GPPAGPGILA WGRGSGNNGV GNIHSGAWGH PSRSTSNGVN GEWGKPPNQH SNSDINGKGS
TGWESPSVTS QNPTVQPGGE HMNSWAKAAS SGTTASEGSS DGSGNHNEGS TGREGTGEGR
RRDKGIIDQG HIQLPRNDLD PRVLSNTGWG QTPVKQNTAW EFEESPRSER KNDNGTEAWG
CAATQPSNSG GKNDGSIMNS TNTSSVSGWV NAPPAAVPAN TGWGDSNNKA PSGPGVWGDS
ISSTAVSTAA AAKSGHAWSG AANQEDKSPT WGEPPKPKSQ HWGDGQRSNP AWSAGGGDWA
DSSSVLGHLG DGKKNGSGWD ADSNRSGSGW NDTTRSGSSG WGNSTNTKAN PGTNWGETLK
PGPQQNWASK PQDNNVSNWG GAASVKQTGT GWIGGPVPVK QKDSSEATGW EEPSPPSIRR
KMEIDDGTSA WGDPSNYNNK TVNMWDRNNP VIQSSTTTNT TTTTTTTSNT THRVETPPPH
QANTQLNRSP LLGPVSSGWG EMPHVHSKTE NSWGEPSSPS PLVDNGTAAW GKPPSSGSGW
GDHPAEPPVA FGRAGAPGAA SALCKPASKS MQEGWGSGGD EMNLSTSQWE DEEGDVWNNA
ASQESASSCS SWGNAPKKGL QKGMKTSGKQ DEAWIMSRLI KQLTDMGFPR EPAEEALKSN
NMNLDQAMSA LLEKKVDVDK RGLGVTDHNG MAAKPLGCRP PISKESSMDR PTFLDKDGGL
VEEPTPSPFL PSPSLKLPLS HSALPSQALG GIASGLGMQN LNSSRQIPSG NLGMFGNSGA
AQARTMQQPP QPPVQPLNSS QPSLRAQVPQ FLSPQVQAQL LQFAAKNIGL NPALLTSPIN
PQHMTMLNQL YQLQLAYQRL QIQQQMLQAQ RNVSGSMRQQ EQQVARTITN LQQQIQQHQR
QLAQALLVKQ PPPPPPPPHL SLHPSAGKSA MDSFPSHPQT PGLPDLQTKE QQSSPNTFAP
YPLAGLNPNM NVNSMDMTSG LSVKDPSQSQ SRLPQWTHPN SMDNLPSAAS PLEQNPSKHG
AIPGGLSIGP PGKSSIDDSY GRYDLIQNSE SPASPPVAVP HSWSRAKSDS DKISNGSSIN
WPPEFHPGVP WKGLQNIDPE NDPDVTPGSV PTGPTINTTI QDVNRYLLKS GGSSPPSSQN
ATLPSSSAWP LSASGYSSSF SSIASAPSVA GKLSDIKSTW SSGPASHTQA SLSHELWKVP
RNTTAPTRPP PGLTNPKPSS TWGASPLGWT SSYSSGSAWS TDASGRTSSW LVLRNLTPQI
DGSTLRTLCL QHGPLITFHL NLTQGNAVVR YSSKEEAAKA QKSLHMCVLG NTTILAEFAG
EEEVNRFLAQ GQALPPTSSW QSSSASSQPR LSAAGSSHGL VRSDAGHWNA PCLGGKGSSE
LLWGGVPQYS SSLWGPPSAD DSRVIGSPTP LTTLLPGDLL SGESL
//
