ID   A0A2K5YUG2_MANLE        Unreviewed;       610 AA.
AC   A0A2K5YUG2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE   AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN   Name=MTMR12 {ECO:0000313|Ensembl:ENSMLEP00000019191.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000019191.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000019191.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC       {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004369}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; A0A2K5YUG2; -.
DR   Ensembl; ENSMLET00000042680.1; ENSMLEP00000019191.1; ENSMLEG00000033704.1.
DR   GeneTree; ENSGT00940000160263; -.
DR   OMA; AFPKEQE; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT   DOMAIN          178..506
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
SQ   SEQUENCE   610 AA;  70628 MW;  40F34419608B893A CRC64;
     EIHTNEKEVT EKEVTLHLLP GEQLLCEAST VLKYVQEDSC QHGVYGRLVC TDFKIAFLGD
     DESALDNDET QFKNKVVGEN DITLHCVDQI YGVFDEKKKT LFGQLKKYPE KLIIHCKDLR
     VFQFCLRYTK EEEVKRIVSG IIHHTQAPKL LKRLFLFSYA TAAQNNTVTD PKNHTIMFDT
     LKDWCWELER TKGNMKYKAV SVNEGYKVCE RLPAYFVVPT PLPEENVQRF QGHGIPIWCW
     SCHNGSALLK MSALPKEQDD GILQIQKSFL DGVYKTIHRP PYEIVKTEDL SSNFLSLQEI
     QTAYSKFKQL FLIDNSTEFW DTDIKWFSLL ESSSWLDIIR RCLKKAIEIT ECMEAQNMNV
     LLLEENASDL CCLISSLVQL MMDPHCRTRI GFQSLIQKEW VMGGHCFLDR CNHLRQNDKE
     EHQRQLSLPL TQSKSSPKRG FFREETDHLI KNLLGKRISK LINSSDELQD NFREFYDSWH
     SKPTDYHGLL LPHIEGPEIK VWAQRYLRWI PEAQILGGSR VATMSKLLEM IEEVQSLQEK
     IDERHHSQQA PQAEAPCLLR NSARLSSLFP FALLQRHSSK PVLPTSGWKA LGDEDDLAKR
     EDEFVDLGDV
//