ID   A0A2K5YVI8_MANLE        Unreviewed;       357 AA.
AC   A0A2K5YVI8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit beta {ECO:0000256|RuleBase:RU362099};
GN   Name=ATP1B4 {ECO:0000313|Ensembl:ENSMLEP00000019572.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000019572.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000019572.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: May act as a transcriptional coregulator during muscle
CC       development through its interaction with SNW1. Has lost its ancestral
CC       function as a Na,K-ATPase beta-subunit.
CC       {ECO:0000256|ARBA:ARBA00037398}.
CC   -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC       which catalyzes the hydrolysis of ATP coupled with the exchange of
CC       Na(+) and K(+) ions across the plasma membrane.
CC       {ECO:0000256|RuleBase:RU362099}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC       pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. Nucleus
CC       inner membrane {ECO:0000256|ARBA:ARBA00037816}; Single-pass type II
CC       membrane protein {ECO:0000256|ARBA:ARBA00037816}.
CC   -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC       {ECO:0000256|ARBA:ARBA00005876, ECO:0000256|RuleBase:RU362099}.
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DR   RefSeq; XP_011832574.1; XM_011977184.1.
DR   AlphaFoldDB; A0A2K5YVI8; -.
DR   STRING; 9568.ENSMLEP00000019572; -.
DR   Ensembl; ENSMLET00000043062.1; ENSMLEP00000019572.1; ENSMLEG00000033985.1.
DR   GeneID; 105537539; -.
DR   KEGG; mleu:105537539; -.
DR   CTD; 23439; -.
DR   GeneTree; ENSGT01030000234579; -.
DR   OMA; KNIRCTH; -.
DR   OrthoDB; 2880589at2759; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 1.
DR   InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR   InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR   NCBIfam; TIGR01107; Na_K_ATPase_bet; 1.
DR   PANTHER; PTHR11523:SF12; PROTEIN ATP1B4; 1.
DR   PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR   Pfam; PF00287; Na_K-ATPase; 1.
DR   PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR   PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|RuleBase:RU362099};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362099};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362099};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362099}; Transport {ECO:0000256|RuleBase:RU362099}.
FT   TRANSMEM        108..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362099"
FT   REGION          26..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..72
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   357 AA;  41639 MW;  11CC8F96122D65C0 CRC64;
     MRRQLRSRRA PSFPYSYRYR LDDPDEVNQN YLADEEEEAE EEARVTVVPK SEEEEEEEEK
     EEEEEEEKEE EEGQGQPTGN AWWQKLQIMN EYLWDPERRM FLARTGQSWS LILLVYFFFY
     ASLAAVITLC MYTLFLTISP YIPTFTERVK PPGVMIRPFA HSLNFNFNVS EPDTWQHYVI
     SLNGFLQGYN DSLQEEMNVD CPPGQYFIQD GNEDEDKKAC QFKRSFLKNC SGLEDPTFGY
     STGQPCILLK MNRVVGFRPE LGDPVKVSCK VQRGDENDIR SISYYPESAS FDLRYYPYYG
     KLTHVNYTSP LVAMHFTDVV KNQAVPVQCQ LKGKGIINDV INDRFVGRVI FTLNIET
//