ID A0A2K5YW97_MANLE Unreviewed; 337 AA.
AC A0A2K5YW97;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=SH3 domain containing GRB2 like 2, endophilin A1 {ECO:0000313|Ensembl:ENSMLEP00000019836.1};
GN Name=SH3GL2 {ECO:0000313|Ensembl:ENSMLEP00000019836.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000019836.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000019836.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the endophilin family.
CC {ECO:0000256|ARBA:ARBA00006697}.
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DR AlphaFoldDB; A0A2K5YW97; -.
DR Ensembl; ENSMLET00000043328.1; ENSMLEP00000019836.1; ENSMLEG00000034118.1.
DR GeneTree; ENSGT00940000160529; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07613; BAR_Endophilin_A1; 1.
DR CDD; cd11803; SH3_Endophilin_A; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035824; Endophilin_A_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF50; ENDOPHILIN-A1; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..234
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 275..334
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 232..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 337 AA; 38290 MW; 309A0CE448E52565 CRC64;
KVSEKVGGAE GTKLDDDFKE MERKVDVTSR AVMEIMTKTI EYLQPNPASR AKLSMINTMS
KIRGQEKGPG YPQAEALLAE AMLKFGRELG DDCNFGPALG EVGEAMRELS EVKDSLDIEV
KQNFIDPLQN LHDKDLREIQ HHLKKLEGRR LDFDYKKKRQ GKIPDEELRQ ALEKFDESKE
IAESSMFNLL EMDIEQVSQL SALVQAQLEY HKQAVQILQQ VTVRLEERIR QASAQPRREY
QPKPRMSLEF PTGDSTQPNG GLSHTGTPKP SGVQMDQPCC RALYDFEPEN EGELGFKEGD
IITLTNQIDE NWYEGMLHGH SGFFPINYVE ILVALPH
//
