ID A0A2K5YWW9_MANLE Unreviewed; 211 AA.
AC A0A2K5YWW9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Suppressor of IKBKE 1 {ECO:0000256|ARBA:ARBA00041003};
DE AltName: Full=Suppressor of IKK-epsilon {ECO:0000256|ARBA:ARBA00042344};
GN Name=SIKE1 {ECO:0000313|Ensembl:ENSMLEP00000020049.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000020049.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000020049.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays
CC an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-
CC mediated activation of interferon-stimulated response elements (ISRE)
CC and the IFN-beta promoter. May act by disrupting the interactions of
CC IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-
CC kappa-B activation pathways. {ECO:0000256|ARBA:ARBA00037749}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SIKE family.
CC {ECO:0000256|ARBA:ARBA00005537}.
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DR RefSeq; XP_011856201.1; XM_012000811.1.
DR AlphaFoldDB; A0A2K5YWW9; -.
DR SMR; A0A2K5YWW9; -.
DR STRING; 9568.ENSMLEP00000020049; -.
DR Ensembl; ENSMLET00000043542.1; ENSMLEP00000020049.1; ENSMLEG00000034245.1.
DR GeneID; 105554357; -.
DR KEGG; mleu:105554357; -.
DR CTD; 80143; -.
DR GeneTree; ENSGT00390000018003; -.
DR OMA; MSKFKPH; -.
DR OrthoDB; 5396923at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR InterPro; IPR008555; SIKE.
DR PANTHER; PTHR12186; SIKE FAMILY MEMBER; 1.
DR PANTHER; PTHR12186:SF4; SUPPRESSOR OF IKBKE 1; 1.
DR Pfam; PF05769; SIKE; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
SQ SEQUENCE 211 AA; 24261 MW; 555B830504AE0EB7 CRC64;
MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQVRQRYQE
DASDMKDMSK YKPHILLSQE NTQIRDLQQE NRELWISLEE HQDALELIMS KYRKQMLQLM
VAKKAVDAEP VLKAHQSHSA EIESQIDRIC EMGEVMRKAV QVDDDQFCKI QEKLAQLELE
NKELRELLSI SSESLQARKE NSMDTASQAI K
//
