ID A0A2K5YX33_MANLE Unreviewed; 1363 AA.
AC A0A2K5YX33;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=MSH6 {ECO:0000313|Ensembl:ENSMLEP00000020097.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000020097.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000020097.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR STRING; 9568.ENSMLEP00000020097; -.
DR Ensembl; ENSMLET00000043590.1; ENSMLEP00000020097.1; ENSMLEG00000034239.1.
DR GeneTree; ENSGT00550000075024; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0032301; C:MutSalpha complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0043531; F:ADP binding; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0000400; F:four-way junction DNA binding; IEA:Ensembl.
DR GO; GO:0032137; F:guanine/thymine mispair binding; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0032405; F:MutLalpha complex binding; IEA:Ensembl.
DR GO; GO:0032357; F:oxidized purine DNA binding; IEA:Ensembl.
DR GO; GO:0032142; F:single guanine insertion binding; IEA:Ensembl.
DR GO; GO:0032143; F:single thymine insertion binding; IEA:Ensembl.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0045190; P:isotype switching; IEA:Ensembl.
DR GO; GO:0006298; P:mismatch repair; IEA:Ensembl.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Ensembl.
DR CDD; cd05837; PWWP_MSH6; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF00855; PWWP; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 95..157
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1363 AA; 153905 MW; 2D2B6CFB3626CC8B CRC64;
MSRQSTLYSF FPKSPALSDA NKASARASRE GGRAAAVPGA SPSLGEDITP LHSSLSDRVR
TCPAYRPPPP PKKENLITYY SYRYKTFKMS CDFSPGDLVW AKMEGYPWWP CLVYNHPFDG
TFIREKGKSV RVHVQFFDDS PTRGWVSKRL LKPYTGSKSK EAQKGGHFYS AKPEILRAMQ
RADEALNKDK IKRLELAVCD EPSEPEEEEE MEVGTTYVTD KSEEDNEIES EEEVQPKTQG
SRRSSRQIKK RRVISDSESD IGGSDVEFKP DTKEEGSSDE ISSGVGDSES EGPNSPVKVA
RKRKRVVTGN GSLKRKSSRK EMPSATKRAT GISSETKNTL SAFSAPQNSE SQAHVSGGGD
DSSRPTVWYH ETLEWLKEEK RRDEHRRRPD HPDFNASTLY VPEDFLNSCT PGMRKWWQIK
SQNFDLVICY KVGKFYELYH MDALIGVSEL GLVFMKGNWA HSGFPEIAFG RYSDSLVQKG
YKVARVEQTE TPEMMEARCR KMAHISKYDR VVRREICRII TKGTQTYSVL EGDPSENYSK
YLLSLKEKEE DSSGHTRAYG VCFVDTSLGK FFIGQFSDDR HCSRFRTLVA HYPPVQVLFE
KGNLSKETKT ILKSSLSSSL QEGLIPGSQF WDASKTLRTL LEEGYFREKL SDDIGVMLPQ
VLKGMTSESD SIGLTPGEKS ELALSALGGC IFYLKKCLID QELLSMANFE EYIPLDSDIV
STTRSGAIFT KAYQRMVLDA VTLNNLEIFL NGTNGSTEGT LLERVDTCHT PFGKRLLKQW
LCAPLCSPYA INDRLDAIED LMVVPDKISE VVELLKKLPD LERLLSKIHN VGSPLKSQNH
PDSRAIMYEE TTYSKKKIID FLSALEGFKV MCKIIGIMEE VIDGFKSKIL KQVISLQTKN
PEGRFPDLTT ELNRWDTAFD HEKARKTGLI TPKAGFDSDY DQALADIREN EQSLLEYLEK
QRNRIGCRTI VYWGIGRNRY QLEIPENFTT RNLPEEYELK STKKGCKRYW TKTIEKKLAN
LINAEERRDV SLKDCMRRLF YNFDKNYKDW QSAVECIAVL DVLLCLANYS RGGDGPMCRP
VILLPEDTPP FLELKGSRHP CITKTFFGDD FIPNDILIGC EEEEQENGKA YCVLVTGPNM
GGKSTLMRQA GLLAVMAQMG CYVPAEVCRL TPIDRVFTRL GASDRIMSGE STFFVELSET
ASILLHATAH SLVLVDELGR GTATFDGTAI ANAVVKELAE TIKCRTLFST HYHSLVEDYS
QNVAVRLGHM ACMVENECED PSQETITFLY KFIKGACPKS YGFNAARLAN LPEEVIQKGH
RKAREFEKMN QSLRLFREVC LASERSTVDA EAVHKLLTLI KEL
//
