ID A0A2K5YY63_MANLE Unreviewed; 1000 AA.
AC A0A2K5YY63;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=NPHS1 adhesion molecule, nephrin {ECO:0000313|Ensembl:ENSMLEP00000020486.1};
GN Name=NPHS1 {ECO:0000313|Ensembl:ENSMLEP00000020486.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000020486.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000020486.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC {ECO:0000256|ARBA:ARBA00008637}.
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DR AlphaFoldDB; A0A2K5YY63; -.
DR Ensembl; ENSMLET00000043984.1; ENSMLEP00000020486.1; ENSMLEG00000034437.1.
DR GeneTree; ENSGT00940000159510; -.
DR OMA; PNMINWY; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11640:SF164; MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1000
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014464990"
FT DOMAIN 27..130
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 242..333
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 340..434
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 440..540
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 639..719
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 736..837
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 839..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 108846 MW; 72C887C3ECC7E2B1 CRC64;
MALGTMLKAP LLLLGLLTEG LAQLAIPASV PRGFWALPEN LTVVEGASVE LRCGVSTPGS
AVQWAKDGLL LGPDPRIPGF PRYRLEGDPA RGEFHLHIEA CDLSDDAEYE CQVGRSEMGP
ELVSPRVILS VLVPPKLLYL TPEAGTVVTW VAGQEYVVSC LSGDAKPAPD ITILLSGQTI
SDISANMNEG SQQKLFTVEA TARVTPQSSD NGQLLVCEAS SPALEAPIKA SFTVNVLFPP
GPPVIEWPGL DEGHVRAGQS LELPCVAQGG NPLATLQWLK NSQPASTAWG TEHTQAVARS
VLVMTVRPED HGARLSCEAH NSVSAGTQER SIMLQVTFSP SAITILGSAS QVENKNVTLS
CVSKSSRPRV LLRWWLGWRQ LLPTEETIMD GLHGGYISMS NLTLLARRED NGLTLTCEAF
SEAFTKETFK KSLTLNVKYP AQKLWIEGAP EGQKLRAGTR VRLVCLAIGG NPEPSLTWYK
DSRTVTESRL PQEPRRMQLG NVEKSGSTFS RELVLVTGPS DNQAKFTCKA GQLSASTQLA
VQYRPEFLGE QVLVVTAVEQ GEALLPVSVS ANPAPEAFNW TFRGYRLSPA GGPRHRILSS
GALHLWNVTR ADDGLYQLHC QNSEGTAEAL LRLDVHYAPT IRALQDPTEV NVGSVDIVCT
VDANPILPGM FSWERLGEDE EDQSLDDMEK ISKGPTGRLR IHQAKLAQAG AYQCIVDNGV
APPARGLVRL VVRFAPQVEH PTPLTKVAAA GDSTSSATLH CRARGVPNIV FTWTKNGVPL
DLQDPRYTEH TYHQGGVHSS LLTIANVSAA QDYALFTCTA TNPLGSDQTN IQLVSISLDQ
PSGEPEDQLP TEPPAGVSGK TEAESEDRVR NEYEESQWTG EQDTRSSTVS TTEAEPYYRS
LRDFSPQLPP TQEEVSYSRG FTGEDEDMAF PGHLYDEVER TYPRSGAWGP LYDEVQMSPW
DLRWPEDAYQ DPRGIYDRVA GDLDTLEPDS LPFELRGHLV
//
