ID   A0A2K5Z3U4_MANLE        Unreviewed;       926 AA.
AC   A0A2K5Z3U4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO6 {ECO:0000313|Ensembl:ENSMLEP00000022484.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000022484.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000022484.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A2K5Z3U4; -.
DR   Ensembl; ENSMLET00000045994.1; ENSMLEP00000022484.1; ENSMLEG00000035299.1.
DR   GeneTree; ENSGT00940000158969; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:UniProt.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..926
FT                   /note="Anoctamin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014328626"
FT   TRANSMEM        314..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        476..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        523..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        686..709
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        743..763
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        841..862
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          77..300
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          303..886
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   926 AA;  108103 MW;  47D10913A9E86A77 CRC64;
     MVAALQAFAH LICFLFLLWF THRVSSNELS FSEELESLDL LENLGQTIIP DLGSLESQND
     FRTPEFEEFN GKSDSLFFND GQRRIDFVLV YEDESRKETS KKGTNEKQRR KRQAYESNLI
     CHGLQLEATR SVLDDKLVFV KVHAPWEVLC TYAEIMHIKL PLKPNDLKNR SSAFGTLNWF
     TKVLSVDESI IKPEQEFFTA PFEKNRMNDF YIVDRDAFFN PATRSRIVYF ILSRVKYQLI
     NNVSKFGINR LVNSGIYKAA FPLHDCKFRR QSEDPSCPNE RYLLYREWAH PRSIYKKQPL
     DLIRKYYGEK IGIYFAWLGY YTQMLLLAAV VGVACFLYGY LNQDNCTWSK EVCHPDIGGK
     IIMCPQCDRL CPFWKLNITC ESSKKLCIFD SFGTLVFAVF MGVWVTLFLE FWKRRQAELE
     YEWDTVELQQ EEQARPEYEA RCTHVVINEI TQEEERIPFT AWGKCIRITL CASAVFFWIL
     LIIASVIGII VYRLSVFIVF SAKLPKNING TDPIQKYLTP QTATSITASI ISFIIIMILN
     TIYEKVAIMI TNFELPRTQT DYENSLTMKM FLFQFVNYYS SCFYIAFFKG KFVGYPGDPV
     YWLGKYRNEE CDPGGCLLEL TTQLTIIMGG KAIWNNIQEV LLPWIMNLIG RFHRVSRSEK
     ITPRWEQDYH LQPMGKLGLF YEYLEMIIQF GFVTLFVASF PLAPLLALVN NILEIRVDAW
     KLTTQFRRLV PEKAQDIGAW QPIMQGIAIL AVVTNAMIIA FTSDMIPRLV YYWSFSVPPY
     GDHTSYTMEG YINNTLSIFK VVDFKNKSKG NPYSELGNHT TCRYRDFRYP PGHPQEYKHN
     IYYWHVIAAK LAFIIVMEHI IYSVKFFISY AIPDVSKRTK SKIQREKYLT QKLLHENHLK
     DMTKNMGVIA ERMIEAVDNN LRPKLE
//