ID A0A2K5Z5F1_MANLE Unreviewed; 1106 AA.
AC A0A2K5Z5F1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 1 {ECO:0000313|Ensembl:ENSMLEP00000023054.1};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSMLEP00000023054.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000023054.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000023054.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR AlphaFoldDB; A0A2K5Z5F1; -.
DR Ensembl; ENSMLET00000046568.1; ENSMLEP00000023054.1; ENSMLEG00000035708.1.
DR GeneTree; ENSGT00940000156915; -.
DR OMA; AGHSAHH; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 499..692
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..997
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 123684 MW; 948A03552C7D1E04 CRC64;
AHCSVEGEAP SSETGTSLDS PSAYPQGPLV PGSSLSPDHY EHTSVGAYGL YSGPPGQQQR
TRRPKLQHST SILRKQAEEE AIKRSRSLSE SYELSSDLQD KQVEMLERKY GGRLVTRHAA
RTIQTAFRQY QMNKNFERLR SSMSENRMSR RIVLSNMRMQ FSFEGPEKVH SSYFEGKQVS
VTNDGSQLGA LVPPECGDLS EPTTLKSPAP SSDFADAITE LEDAFSRQVK SLAESIDDAL
NCRSLHTEEA PALDVARARD TEPQTALHSM DHRKLDEMTA SYSDVTLYID EEELSPPLPL
SQAGDRPSST ESDLRLRAGG AAPDYWALAH KEDKADTDTS CRSTPSLERQ EQRLRVEHLP
LLTIEPPSDS SVDLSDRSER GSLKRQSAYE RSLGGQQSSP KHGPHSGPPK SLPREEPELR
PRPPRPLDSH LAINGSANRQ SKSESDYSDG DNDSINSTSN SNDTINCSSE SSSRDSLREQ
TLSKQTYHKE ARNSWDSPAF SNDVIRKRHY RIGLNLFNKK PEKGVQYLIE RGFVPDTPVG
VAHFLLQRKG LSRQMIGEFL GNRQKQFNRD VLDCVVDEMD FSTMELDEAL RKFQAHIRVQ
GEAQKVERLI EAFSQRYCIC NPGVVRQFRN PDTIFILAFA IILLNTDMYS PNVKPERKMK
LEDFIKNLRG VDDGEDIPRE MLIGIYERIR KRELKTNEDH VSQVQKVEKL IVGKKPIGSL
HPGLGCVLSL PHRRLVCYCR LFEVPDPNKP QKLGLHQREI FLFNDLLVVT KIFQKKKNSV
TYSFRQSFSL YGMQVLLFEN QYYPNGIRLT SSVPGADIKV LINFNAPNPQ DRKKFTDDLR
ESIAEVQEME KHRIESELEK QKGVVRPSMS QCSSLKKESG NGTLSRACLD DSYASGEGLK
RSALSSSLRD LSEAGKRGRR SSAGSLESNV EGSIISSPHM RRRATSTREC PSRPHQTMPN
SSSLLGSLFG SKRGKPPPQA HLPSAPAPPP PHPPVVLPHL QHSVAGHHLG PPEGLPQAPV
HGHHTQYCHM QQNPPPYHHH HHHHPPQHIQ HAHQYHHGPH GGAHTLAPCP MPVSATGSPS
ILQTIQGPCK RSWEQKFPEI PSSASV
//
