ID A0A2K5Z6E6_MANLE Unreviewed; 716 AA.
AC A0A2K5Z6E6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Component of inhibitor of nuclear factor kappa B kinase complex {ECO:0000313|Ensembl:ENSMLEP00000023396.1};
GN Name=CHUK {ECO:0000313|Ensembl:ENSMLEP00000023396.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000023396.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000023396.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K5Z6E6; -.
DR Ensembl; ENSMLET00000046911.1; ENSMLEP00000023396.1; ENSMLEG00000035776.1.
DR GeneTree; ENSGT00950000182937; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008384; F:IkappaB kinase activity; IEA:InterPro.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProt.
DR GO; GO:0009967; P:positive regulation of signal transduction; IEA:UniProt.
DR CDD; cd17046; Ubl_IKKA_like; 1.
DR Gene3D; 1.20.1270.250; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041185; IKBKB_SDD.
DR InterPro; IPR046375; IKBKB_SDD_sf.
DR InterPro; IPR022007; IKKbetaNEMObind.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF13; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA; 1.
DR Pfam; PF18397; IKBKB_SDD; 1.
DR Pfam; PF12179; IKKbetaNEMObind; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM01239; IKKbetaNEMObind; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 15..284
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 716 AA; 81599 MW; C0D9EE207809A2E2 CRC64;
MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL STKNRERWCH
EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ
ILSLLSDIVL KYHYLKPENI IIHKIIDLGY AKDVDQGSLC TSFVGTLQYL APELFENKPY
TATVDYWSFG TMVFECIAGY RPFLHHLQPF TWHEKIKKKD PKCIFACEEM SGEVRFSSHL
PQPNSLCSLI VEPMENWLQL MLNWDPQQRG GPVDLTLKQP RCFVLMDHIL NLKIVHILNM
TSAKIISFLL PPDESLHSLQ SRIERETGIN TGSQELLSET GISLDPRKPA SQCVLDGVRG
CDSYMVYLFD KSKTVYEGPF ASRSLSDCVN YIVQDSKIQL PIVQLRKVWA EAVHYVSGLK
EDYSRLFQGQ RAAMLSLLRY NANLTKMKNT LISASQQLKA KLEFFHKSIQ LDLERYSEQM
TYGISSEKML KAWKEMEEKA IHYAEVGVIG YLEDQIMSLH AEIMELQKSP YGRRQGDLME
SLEQRAIDLY KQLKHRPSDH SYSDSTEMVK IIVHTVQSQD RVLKELFGHL SKLLGCKQKI
IDLLPKVEVA LSNIKEADNT VMFMQGKRQK EIWHLLKIAC TQSSARSLVG SSLEVWLPPT
SAEHDHSLSC VVTPQDGDTS AQMIEENLNC LGHLSTIIHE ANEEQGNSMM VTWVTE
//
